Going nuclear in metabolic and cardiovascular disease

The Journal of Clinical Investigation
Christopher K Glass

Abstract

Estrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Recent studies of the biologic roles of these receptors and their mechanisms of action have significantly advanced our understanding of transcriptional programs that control lipid and carbohydrate metabolism, immunity and inflammation, and wound repair. These findings provide insights into the therapeutic actions of existing drugs that target nuclear receptors and raise new possibilities for development of safer, more effective drugs for the prevention and treatment of metabolic and cardiovascular diseases. In this introduction to this Review series, underlying mechanisms that enable nuclear receptors to positively and negatively regulate gene expression are presented as background to the focused reviews on estrogen receptors, PPARs, liver X receptors, and the PPARgamma coactivator-1 (PGC-1) family of coactivators.

References

Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
May 1, 1995·Genes & Development·P J WillyD J Mangelsdorf
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Dec 15, 1995·Cell·D J Mangelsdorf, R M Evans
Jun 16, 1999·Endocrine Reviews·N J McKennaB W O'Malley
Oct 26, 1999·Endocrine Reviews·V Giguère
Dec 1, 2001·Science·A ChawlaD J Mangelsdorf
Dec 26, 2001·Nucleic Acids Research·Jorge DuarteMarc Robinson-Rechavi
Jul 11, 2002·The American Journal of Cardiology·Michael E Mendelsohn
Apr 12, 2003·Molecular Endocrinology·Peter Tontonoz, David J Mangelsdorf
Oct 14, 2004·Cell·Bruce M Spiegelman, Reinhart Heinrich
Jul 22, 2005·The Cochrane Database of Systematic Reviews·C M FarquharUNKNOWN Cochrane HT Study Group
Nov 5, 2005·Journal of Cellular Physiology·Bramanandam Manavathi, Rakesh Kumar
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Mar 3, 2006·The Journal of Clinical Investigation·Philippe LefebvreBart Staels
Mar 3, 2006·The Journal of Clinical Investigation·Robert K SempleStephen O'Rahilly
Mar 3, 2006·The Journal of Clinical Investigation·Grant D BarishRonald M Evans
Mar 3, 2006·The Journal of Clinical Investigation·Liliane Michalik, Walter Wahli
Mar 3, 2006·The Journal of Clinical Investigation·Noam Zelcer, Peter Tontonoz
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly

❮ Previous
Next ❯

Citations

Jul 16, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gary LandrethMichael Heneka
Feb 5, 2011·Acta Pharmacologica Sinica·Sunhyo Jeong, Michung Yoon
Feb 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana González-PérizJoan Clària
Aug 28, 2009·Genes & Development·Nan WuMitchell A Lazar
Jul 5, 2007·Annual Review of Pharmacology and Toxicology·Jean-Marc PascussiPatrick Maurel
Sep 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Louiza BelkacemiMichael G Ross
Jun 21, 2011·Journal of Lipid Research·Yipeng SuiChangcheng Zhou
Apr 12, 2014·Biochemical Pharmacology·Krisstonia SpruiellMaxwell A Gyamfi
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Josep A VillenaAnastasia Kralli
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Amir ShlomaiYosef Shaul
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·E RozemaB Kopp
Sep 28, 2010·PPAR Research·Michung Yoon
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Michael Murray
Jan 31, 2016·Biochimica Et Biophysica Acta·Xavier PalomerManuel Vázquez-Carrera
Sep 30, 2009·Molecular and Cellular Endocrinology·Xiaohong JiangChen-Yu Zhang
Oct 30, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Marta C AbadDionisios Rentzeperis
Sep 18, 2007·Biochimie·Amelia Casamassimi, Claudio Napoli
Nov 28, 2012·Molecular Nutrition & Food Research·Tsuyoshi GotoTeruo Kawada
Mar 9, 2013·Molecular Nutrition & Food Research·Tsuyoshi GotoSatoshi Nagaoka
Jan 12, 2010·Biochemical Pharmacology·Andrea A CronicanIliya Lefterov
May 25, 2011·The Biochemical Journal·Tsuyoshi GotoTeruo Kawada
Dec 22, 2010·Biochimica Et Biophysica Acta·Eckardt Treuter, Nicolas Venteclef
Jun 6, 2008·PPAR Research·Moray J CampbellH Phillip Koeffler
Feb 16, 2012·Cell Cycle·Shin-ichi OkaJunichi Sadoshima
Mar 17, 2015·Current Atherosclerosis Reports·David Bishop-Bailey
Nov 18, 2006·The International Journal of Biochemistry & Cell Biology·Ajay K MudduDerek A Mann

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
hormone replacement therapy

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Nature Reviews. Immunology
Christopher K Glass, Sumito Ogawa
The Journal of Clinical Investigation
Robert K SempleStephen O'Rahilly
The Journal of Clinical Investigation
Grant D BarishRonald M Evans
© 2021 Meta ULC. All rights reserved