Going to extremes - a metagenomic journey into the dark matter of life.

FEMS Microbiology Letters
Arnthór AevarssonRuoshi Zhang

Abstract

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·F W StudierJ W Dubendorff
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R W HendrixG F Hatfull
Oct 4, 2000·Nature Structural Biology·D ChristendatC H Arrowsmith
Oct 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mya BreitbartForest Rohwer
Jul 2, 2003·Current Opinion in Microbiology·Bertus van den Burg
Mar 10, 2004·Applied and Environmental Microbiology·Mya BreitbartForest Rohwer
Jun 3, 2004·The Lancet Infectious Diseases·Samuel Yang, Richard E Rothman
Dec 8, 2004·The Journal of Biological Chemistry·Thorarinn BlondalJakob K Kristjansson
May 12, 2005·Nature Reviews. Microbiology·Robert A Edwards, Forest Rohwer
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jonathan FiléeH M Krisch
Jun 1, 1996·Applied and Environmental Microbiology·M MiddelboeN Kroer
Jul 6, 2006·Cellular Microbiology·Roman Dziarski, Dipika Gupta
Aug 26, 2006·Genome Biology·Roman Dziarski, Dipika Gupta
Nov 9, 2006·PLoS Biology·Florent E AnglyForest Rohwer
May 2, 2007·Current Biology : CB·Noreen E Murray, Alexander Gann
Nov 21, 2008·The Journal of Biological Chemistry·Santina RussoEhmke Pohl
Aug 4, 2009·Research in Microbiology·Patrick Forterre, David Prangishvili
Oct 17, 2009·Nature Reviews. Microbiology·Francisco Rodriguez-ValeraAlex Mira
Oct 24, 2009·Current Opinion in Biotechnology·Taku Uchiyama, Kentaro Miyazaki
Nov 10, 2009·Trends in Microbiology·Thomas SchoenfeldDavid Mead
Nov 28, 2009·Trends in Microbiology·David M KristensenEugene V Koonin
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Jun 21, 2011·Bacteriophage·Martha Rj ClokieShaun Heaphy
Feb 3, 2012·Advances in Experimental Medicine and Biology·Lindsay W Black, Julie A Thomas
Mar 24, 2012·Current Opinion in Virology·Karyna Rosario, Mya Breitbart
Mar 24, 2012·Current Opinion in Virology·John L MokiliBas E Dutilh
Sep 14, 2012·Frontiers in Microbiology·Niko BeerenwinkelKarin J Metzner
Jan 1, 2013·Bacteriophage·Jochen KlumppShanmuga Sozhamannan
Mar 5, 2013·Trends in Microbiology·Jesse P HarrisonCharles S Cockell
Jun 12, 2013·Protein Engineering, Design & Selection : PEDS·Robert H WilsonWayne M Patrick
Dec 10, 2013·Extremophiles : Life Under Extreme Conditions·Sigridur HjorleifsdottirJakob K Kristjansson
Jan 28, 2014·PloS One·Shasha LiYigang Tong
Nov 18, 2014·Nature Methods·Benjamin BuchfinkDaniel H Huson

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