Goitrous hypothyroidism associated with treatment with trimethoprim-sulfamethoxazole in a young dog

Journal of the American Veterinary Medical Association
Davis M SeeligPaul R Avery

Abstract

A 16-week-old female Boxer that had been treated for 5 weeks with trimethoprim-sulfamethoxazole and chloramphenicol because of aspiration pneumonia was evaluated for bilaterally symmetric masses in the subcutaneous tissues of the ventral neck, in the region of the larynx. Fine-needle aspirates were obtained from the neck masses; cytologic examination revealed well-differentiated thyroid epithelial tissue. A blood sample was collected for serum biochemical and thyroid function analyses. Mild hyperphosphatemia, severe hypercholesterolemia, mild hyperkalemia, and a mild increase in creatine kinase activity were identified. Serum concentration of total thyroxine was less than the lower reference limit, and that of thyroid-stimulating hormone was greater than the upper reference limit. Findings were consistent with a diagnosis of clinical hypothyroidism in a skeletally immature dog. Treatment with trimethoprim-sulfamethoxazole was discontinued. The dog was reevaluated 3 weeks later, at which time the neck masses were markedly decreased in size. Serum concentrations of cholesterol and potassium were lower; serum concentrations of total thyroxine and thyroid-stimulating hormone were near or within respective reference ranges. Age-appr...Continue Reading

References

Dec 1, 1996·Kidney International·I W ReiserJ G Porush
Mar 24, 1999·The Journal of Small Animal Practice·R M Dixon, C T Mooney
Jan 6, 2000·Regulatory Toxicology and Pharmacology : RTP·L A PoirierB A Schwetz
Feb 22, 2000·The Science of the Total Environment·M CleemannR Dietz
Feb 5, 2002·Molecular Genetics and Metabolism·Clare B HarveyGraham R Williams
Mar 20, 2002·Domestic Animal Endocrinology·I A SchaafsmaM E Everts
Sep 27, 2002·Journal of the American Veterinary Medical Association·Nicola L WilliamsonKeith A Hnilica
Feb 5, 2003·Journal of Veterinary Internal Medicine·John C FyfeVirginia M Fetro
Jan 1, 1993·Veterinary Clinical Pathology·Robin K. SaneckiDavid J. Schaeffer
Aug 2, 2003·Journal of Veterinary Internal Medicine·Sylvie Daminet, Duncan C Ferguson
Aug 1, 1964·The Journal of Clinical Investigation·J CORVILAIN, M ABRAMOW
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·J H Duncan Bassett, Graham R Williams
Sep 10, 2004·Clinical Endocrinology·Elaine Murphy, Graham R Williams
Mar 11, 2005·American Journal of Veterinary Research·Linda A FrankJacqueline A Davis
Sep 24, 2005·Medicine and Science in Sports and Exercise·Bertrand TehardJean-Michel Oppert
Jan 6, 2006·Endocrine Research·Zeliha Hekimsoy, Iris Kavalali Oktem

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Citations

Nov 2, 2012·Journal of Veterinary Internal Medicine·S E DodgsonJ C Fyfe
May 23, 2012·Journal of the American Animal Hospital Association·Leslie Anne KuczynskiUrs Giger
Aug 25, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Olivier Taeymans, Shana K O'Marra
Nov 26, 2009·Australian Veterinary Journal·K BrennerT Schermerhorn
Jul 29, 2011·The Veterinary Journal·Lisa A RadostaIlana R Reisner
Dec 16, 2017·Clinical Medicine Insights. Pathology·Davinson C AnyoguJohn I Ihedioha
Oct 9, 2018·Journal of Veterinary Internal Medicine·Mark E PetersonMark Rishniw

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