Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women

European Journal of Applied Physiology
E TamC Capelli

Abstract

We investigated the effects of moderate-intensity training at low and high altitude on VO2 and QaO2 kinetics and on myosin heavy-chain expression (MyHC) in seven women (36.3 yy ± 7.1; 65.8 kg ± 11.7; 165 cm ± 8) who participated in two 12- to 14-day trekking expeditions at low (598 m) and high altitude (4132 m) separated by 4 months of recovery. Breath-by-breath VO2 and beat-by-beat QaO2 at the onset of moderate-intensity cycling exercise and energy cost of walking (Cw) were assessed before and after trekking. MyHC expression of vastus lateralis was evaluated before and after low-altitude and after high-altitude trekking; muscle fiber high-resolution respirography was performed at the beginning of the study and after high-altitude trekking. Mean response time of VO2 kinetics was faster (P = 0.002 and P = 0.001) and oxygen deficit was smaller (P = 0.001 and P = 0.0004) after low- and high-altitude trekking, whereas ˙ QaO2 kinetics and Cw did not change. Percentages of slow and fast isoforms of MyHC and mitochondrial mass were not affected by low- and high-altitude training. After training altitude, muscle fiber ADP-stimulated mitochondrial respiration was decreased as compared with the control condition (P = 0.016), whereas leak...Continue Reading

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Citations

Jul 30, 2016·Frontiers in Physiology·Rosa MancinelliTiziana Pietrangelo
May 7, 2019·Frontiers in Physiology·Tobias DünnwaldWolfgang Schobersberger
Oct 25, 2017·Frontiers in Physiology·Gianluca VernilloGuillaume Y Millet
Jul 7, 2020·European Journal of Sport Science·Laura MagliuloVittore Verratti
Jan 7, 2016·Frontiers in Physiology·Tiziana PietrangeloStefania Fulle
Jan 9, 2019·Frontiers in Physiology·Leonardo Alexandre Peyré-Tartaruga, Marcelo Coertjens
Nov 24, 2016·Frontiers in Physiology·Gianluca VernilloFederico Schena

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