Gold-catalyzed formation of aryl-fused pyrazolooxazepines via intramolecular regioselective 7-exo-dig cyclization

Organic & Biomolecular Chemistry
Ravinder GuduruGalla V Karunakar

Abstract

An efficient method was developed for the synthesis of substituted aryl-fused pyrazolooxazepines from ortho-O-propargyl aryl pyrazoles by gold catalysis. In this organic transformation a new C-N bond was formed regioselectively via 7-exo-dig cyclization. Moderate to good yields of aryl-fused pyrazolooxazepine derivatives were obtained with significant molecular complexity in one-pot.

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Citations

Jun 4, 2019·Organic & Biomolecular Chemistry·Komalla SunilGalla V Karunakar
Jul 1, 2020·Chemistry : a European Journal·Debojyoti Bag, Sanghapal D Sawant
Apr 29, 2021·Organic & Biomolecular Chemistry·Chittala Emmaniel RajuGalla V Karunakar
Aug 29, 2019·The Journal of Organic Chemistry·Veerabhushanam KadiyalaGalla V Karunakar

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Methods Mentioned

BETA
X-ray
column chromatography

Software Mentioned

Bruker Apex
SHELXL

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