Gold-catalyzed intramolecular carbocyclization of alkynyl ketones leading to highly substituted cyclic enones

Organic Letters
Tienan Jin, Yoshinori Yamamoto


The reaction of the internal alkynyl ketones 1 (n=1) under the combined catalyst, AuCl3 and AgSbF6, gave the enones 2 in good to high yields, whereas that of the terminal alkynyl ketones 1 (n=0) under the combined catalyst, AuCl3 and AgOTf, afforded the cyclic enones 3.


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