Gold. Effective therapy for mucosal lesions of pemphigus vulgaris

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
D LangeM Fischer

Abstract

High-dose steroids in combination with other immunosuppressant substances, usually azathioprine, are the therapy of choice in pemphigus vulgaris. Complete remission can be difficult to achieve, with mucosal lesions often recalcitrant. We describe two patients in whom gold in the form of sodium aurothiomalate was effective in resolving mucosal lesions. Initially both patients were treated with high-dose corticosteroids, one in combination with mycophenolate mofetil. Their oral lesions proved to be stubborn but responded well to intramuscular gold, which also showed a steroid-sparing effect, so that the dosage of corticosteroids could be reduced to a minimum. Sodium aurothiomalate was continued until both patients were in remission without any side effects.

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Citations

Jun 29, 2013·Clinics in Dermatology·Eleonora RuoccoAda Lo Schiavo
Dec 6, 2011·Clinics in Dermatology·Michael KasperkiewiczDetlef Zillikens
Apr 29, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity

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