Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial-mesenchymal transition inhibition

International Journal of Nanomedicine
Wei LiYunlong Pan

Abstract

Angiogenesis is a process by which vessels are formed through preexisting ones, and this plays a key role in the progression of solid tumors. However, tumor vessels are influenced by excessive pro-angiogenic factors, resulting in deformed structures that facilitate the intravasation of tumor cells into the circulation and subsequent metastasis. Moreover, abnormal tumor vessels have low blood perfusion and thereby decreased oxygen infusion into tumors. This results in a hostile microenvironment that promotes epithelial-mesenchymal transition (EMT), a process in which epithelial cells lose their polarity and gain increased motility, which is associated with metastasis and invasion. Here, we demonstrate that gold nanoparticles (AuNPs) facilitate tumor vasculature normalization, increase blood perfusion and alleviate hypoxia in melanoma tumors. Additionally, AuNPs were observed to reverse EMT in tumors, accompanied by the alleviation of lung metastasis. These AuNPs inhibited the migration of B16F10 cells and reversed EMT in B16F10 cells, indicating that AuNPs could directly regulate EMT independent of improvements in hypoxia. Taken together, our data demonstrated that AuNPs could induce tumor vasculature normalization and reverse E...Continue Reading

Citations

Sep 3, 2019·Frontiers in Bioengineering and Biotechnology·Catarina Roma-RodriguesPedro V Baptista
Dec 5, 2019·Frontiers in Oncology·George Mattheolabakis, Constantinos M Mikelis
Sep 10, 2020·International Journal of Nanomedicine·Sun Young ParkYoung-Whan Choi
Nov 30, 2018·Biomaterials Science·Vladimir Mulens-AriasFlorence Gazeau
Jan 5, 2021·Medical Oncology·Jamal Majidpoor, Keywan Mortezaee
Jan 8, 2021·Frontiers in Immunology·Wei LiMin Cui
Jan 29, 2021·Critical Reviews in Oncology/hematology·Mário EstevesJosé Alberto Duarte
Dec 3, 2020·International Journal of Molecular Sciences·Joanna DepciuchMagdalena Parlinska-Wojtan
Mar 4, 2021·International Journal of Molecular Sciences·Kamil BrzoskaMarcin Kruszewski
Jun 25, 2021·Frontiers in Pharmacology·Jia-Shuai HeJing-Hua Pan

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering

Software Mentioned

GraphPad Prism
ImageJ
Quantity One

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