Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer's type

Materials Science & Engineering. C, Materials for Biological Applications
Alexandre P MullerPaulo Cesar Lock Silveira

Abstract

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia in the aged brain. Even though its etiology is unknown, factors such as neuroinflammation, mitochondrial dysfunction, formation of reactive oxygen species (ROS), and impaired insulin signaling may play a role. We used a sporadic AD model in rats generated by intracerebroventricular-streptozotocin (i.c.v.-STZ) injection to test the therapeutic effect of gold nanoparticles (GNPs). We tested the null hypothesis that there would be no difference between the STZ+GNPs group and the STZ group in the analyzed markers. We observed that STZ-induced impairment in mitochondrial ATP production, neuroinflammation, and oxidative stress were all prevented by GNP treatment. Moreover, while STZ induced deficits in both spatial and recognition memory, GNPs prevented this effect. These results suggest that GNPs may be considered as a potential treatment for dementias.

Citations

Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khalid Elfaki IbrahimHaseeb Ahmad Khan
Apr 3, 2019·Journal of Biochemical and Molecular Toxicology·Shalabh Pandey, Awanish Mishra
May 3, 2019·Journal of Drug Targeting·Daniela Pacheco Dos Santos HaupenthalPaulo Cesar Lock Silveira
Sep 11, 2019·Journal of Biomedical Materials Research. Part a·Daniela Pacheco Dos Santos HaupenthalPaulo Cesar Lock Silveira
Oct 23, 2019·Drug Delivery and Translational Research·Ghada AlomariMurtaza M Tambuwala
Oct 16, 2019·Molecular Neurobiology·Natalia Dos Santos TramontinAlexandre Pastoris Muller
Apr 2, 2020·Pharmaceutics·Carmem Jane Ferreira VilarCaroline Addison Carvalho Xavier de Medeiros
May 28, 2019·Journal of Cellular Biochemistry·Talíria Silva LopesPaulo Emílio Corrêa Leite
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Julio A Flores-CuadraMaria B Carreira
Feb 21, 2021·Journal of Nanobiotechnology·Davide Di BellaStephen F Rodrigues
Mar 25, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Daniela Pacheco Dos Santos HaupenthalPaulo Cesar Lock Silveira
Feb 23, 2021·Colloids and Surfaces. B, Biointerfaces·Matheus Scarpatto RodriguesJade de Oliveira
Jan 19, 2021·ACS Biomaterials Science & Engineering·Carolini MendesPaulo Cesar Lock Silveira
Apr 29, 2021·Neural Regeneration Research·Gustavo de Bem SilveiraPaulo Cesar Lock Silveira
May 1, 2021·Nanomaterials·Joanna SobskaKatarzyna Matczyszyn
Jun 15, 2021·Frontiers in Pharmacology·Feng-Dan ZhuAn-Guo Wu
Jul 9, 2021·Environmental Science and Pollution Research International·Hend M HussienSamar R Saleh

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