Gold Nanorods Bioconjugates for Intracellular Delivery and Cancer Cell Apoptosis

Journal of Laboratory Automation
Shouhui ChenXianting Ding

Abstract

The aim of this study was to identify an improved delivery scheme for intracellular delivery and anticancer therapy. Novel gold nanorods (GNRs) bioconjugates were prepared by using GNRs as nonviral vectors conjugated with thiol-modified antisense oligodeoxynucleotides (ASODNs). We then investigated the possibility of using GNRs as carriers for nucleus delivery of ASODNs genes by using confocal microscopy and cell transmission electron microscope imaging. Our results demonstrate that the GNRs-ASODNs entered into the cell nucleus and increased cell apoptosis. Therefore, the GNRs could hold great promise for biological delivery applications and gene therapy.

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Citations

Jul 22, 2015·Journal of Laboratory Automation·Xianting Ding
Aug 11, 2021·Cell Biochemistry and Function·Farshid Qiyami HourMehdi Mehdizadeh

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Methods Mentioned

BETA
transfection
biosensing
antisense oligodeoxynucleotides
confocal
flow cytometry
fluorescence imaging

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