Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development

Metallomics : Integrated Biometal Science
Aloysious SsemagandaMichael F Good

Abstract

Here, the anti-malarial activity of two gold(i) phosphine compounds auranofin and [Au(d2pype)2]Cl (where d2pype is 1,2-bis(di-2-pyridylphosphino)ethane), were examined to inform their use as potential drugs and malaria parasite-attenuating agents. In vitro, the gold compounds were active against Plasmodium falciparum and P. knowlesi as well as the rodent parasite P. chabaudi AS. Attenuation of the parasite was observed when mice were inoculated with P. chabaudi AS infected red blood cells treated in vitro with [Au(d2pype)2]Cl (1 or 2 μM) or auranofin (2 μM) for 2 or 3 h. Quantitative PCR data showed persistence of low levels of parasite DNA up to 8 days post inoculation. In some experiments, there was microscopically detectable parastiemia following inoculation which subsequently cleared. Following 1 or 3 doses of gold compound-treated parasitized red blood cells (pRBCs), protection was not observed when these mice were subsequently challenged with wild type P. chabaudi AS. In experiments where microscopically detectable parasites were observed following in vivo inoculation, mice were subsequently fully protected against a challenge infection with wildtype parasites. In an infect-and-treat rodent model, the gold compounds were ...Continue Reading

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·V N GladyshevT C Stadtman
Sep 30, 2000·European Journal of Biochemistry·C H WilliamsR H Schirmer
Sep 30, 2000·European Journal of Biochemistry·K BeckerS Müller
Dec 29, 2000·Cancer Chemotherapy and Pharmacology·M J McKeageB C Baguley
Dec 26, 2001·Chemical Reviews·C F Shaw III
May 11, 2002·The Journal of Biological Chemistry·Zita KrnajskiSylke Müller
Mar 24, 2004·International Journal for Parasitology·Katja BeckerHagai Ginsburg
Jan 24, 2006·Nucleic Acids Research·Alexey V LobanovVadim N Gladyshev
Dec 11, 2007·The Journal of Biological Chemistry·Alvaro Molina-CruzCarolina Barillas-Mury
Feb 16, 2008·The Journal of Infectious Diseases·Stephanie K YanowTerry W Spithill
Aug 28, 2009·The Journal of Biological Chemistry·Francesco AngelucciAndrea Bellelli
May 13, 2010·Malaria Journal·Ioana AlesutanFlorian Lang
May 31, 2011·Current Topics in Medicinal Chemistry·Francesco AngelucciAndrea Bellelli
Jul 15, 2011·Metallomics : Integrated Biometal Science·Susan J Berners-Price, Aleksandra Filipovska
Dec 15, 2011·Journal of Inorganic Biochemistry·Fulvio SaccocciaAndrea Bellelli
Dec 20, 2011·Biochemical and Biophysical Research Communications·Antonia CaroliAllegra Via
Aug 15, 2012·Biochemical and Biophysical Research Communications·Giovanna BoumisAdriana E Miele
Sep 4, 2012·International Journal of Medical Microbiology : IJMM·Esther Jortzik, Katja Becker
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert W MoonMichael J Blackman
Jul 19, 2013·The Journal of Clinical Investigation·Michael F GoodVirginia McPhun
Apr 27, 2016·Antimicrobial Agents and Chemotherapy·Megan S J ArnoldKatherine T Andrews
May 10, 2017·Biochemical and Biophysical Research Communications·Rahul ChaudhariSwati Patankar

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Citations

Jan 4, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Gowtham SubramanianRajesh Chandramohanadas
Mar 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Isao MomoseManabu Kawada
Jun 12, 2021·Metallomics : Integrated Biometal Science·Elisa AbásLaura Grasa
Dec 17, 2019·Journal of Medicinal Chemistry·Emily K DennisSylvie Garneau-Tsodikova

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Datasets Mentioned

BETA
DQ241815.1

Methods Mentioned

BETA
PCR

Software Mentioned

Rad CFX Manager
GraphPad Prism

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