PMID: 6164953May 1, 1981Paper

Golgi and electronmicroscopic studies of spongiform encephalopathy

Neurology
D M LandisC L Masters

Abstract

Golgi impregnations of cerebral biopsies from two patients suffering from Creutzfeldt-Jakob disease (subacute spongiform encephalopathy) revealed striking loss of dendritic spines of pyramidal neurons and unusual focal spherical distensions of dendritic and axonal processes. Light and electronmicroscopic studies disclosed spongiform changes, which seemed to be caused by intracytoplasmic vacuoles and expansion of the plasmalemmal membranes of neurons and astrocytes. Although the diagnostic biopsies were performed at a markedly symptomatic stage of the disease, there was no evidence of neuronal cell loss. Neuronal changes in Golgi impregnations of cerebral cortex from hamsters infected with scrapie were essentially identical to those in the human biopsies. The loss of dendritic spines of pyramidal cells and spherical swellings of axons and dendrites thus seem to be characteristic of spongiform encephalopathies, and probably account in part for the clinical neurologic manifestations, which may be severe in the relative absence of neuronal death.

Citations

Jun 28, 2000·Microscopy Research and Technique·K L MoyaL Di Giamberardino
Jan 1, 1986·Acta Neuropathologica·F UdakaM Tomonaga
Jan 1, 1985·Acta Neuropathologica·T KatoJ F Llena
Jan 1, 1985·Acta Neuropathologica·T Kato, A Hirano
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J BercianoM Lafarga
Jan 1, 1989·Journal of the Neurological Sciences·J H Kim, E E Manuelidis
Jun 22, 1990·Neuroscience Letters·I FerrerT Tuñón
Jan 1, 1995·Micron : the International Research and Review Journal for Microscopy·M JeffreyC M Goodsir
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R S DombroM D Norenberg
Sep 28, 1998·The European Journal of Neuroscience·N SalèsK L Moya
Mar 8, 1984·The New England Journal of Medicine·S B Prusiner
Jul 31, 1986·The New England Journal of Medicine·M G HarringtonD C Gajdusek
Dec 1, 1993·Neuropathology and Applied Neurobiology·S Patt, L Gerhard
Jan 7, 2014·Neural Plasticity·Zuzana Šišková, Marie-Ève Tremblay
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·Beata SikorskaPaul Brown
Mar 1, 1995·Medical Hypotheses·L CalandrielloG Palladini
Nov 6, 2004·The Journal of Biological Chemistry·Malin K Sandberg, Peter Löw
Mar 1, 1986·Neuropathology and Applied Neurobiology·E G Gray
Jan 1, 1983·Acta Neuropathologica·I FerrerJ M Grau Veciana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Canavan Disease

Canavan disease, a type of leukodystrophy, is an autosomal recessive neurodegenerative disorder, and is one of the most common degenerative cerebral diseases of infancy. Discover the latest research on Canavan disease here.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Neuropathology and Experimental Neurology
J H Kim, E E Manuelidis
Neuropathology and Applied Neurobiology
Isidro FerrerJ M Grau Veciana
© 2021 Meta ULC. All rights reserved