Golgi Fragmentation in Human Patients with Chronic Atrial Fibrillation: A New Aspect of Remodeling

The Thoracic and Cardiovascular Surgeon
Luisa JungkStefan Dhein

Abstract

Atrial fibrillation (AF) is the most common chronic arrhythmia in elderly people and is accompanied by remodeling processes. While much is known about changes in ionic channels and in extracellular matrix, less is known about possible changes of intracellular structures. We wanted to investigate, whether AF may also affect the structure of the Golgi apparatus and the microtubular network. One-hundred fifty-three cardiac surgery patients were investigated [n = 24 in sinus rhythm (SR) and n = 129 with chronic AF of >1 year duration]. Tissue samples of the left atrial free wall were examined immunohistochemically. Golgi apparatus was detected by GM130 and its phosphorylated isoform. Furthermore, we investigated the length of the microtubules by α-tubulin staining. We also measured stathmin (phospho-S37), which is known to induce microtubule depolymerization. In addition, we investigated the cyclin-dependent kinase cdk5-activation, a typical stimulus for Golgi fragmentation, by measuring membrane-associated cdk5. We found significant fragmentation of the Golgi apparatus in AF together with a reduced fragment size. Significant more fragments of the Golgi were found lateral to the nucleus in AF, while the Golgi in SR was located more...Continue Reading

Citations

Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Jie ZhangLiuwang Zeng
Jul 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Nils BäckBetty A Eipper

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