Golgi protein 73 as a biomarker for hepatocellular carcinoma: A diagnostic meta-analysis

Experimental and Therapeutic Medicine
Jing YangChuanyong Guo

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and the third leading cause of cancer-related mortality worldwide. Conflicting results have been reported regarding the use of serum Golgi protein 73 (GP73) as a promising serum marker for the diagnosis of HCC; therefore, the aim of the present study was to provide a systematic review of the diagnostic performance of GP73 for HCC. Following a systematic review of the relevant studies, a number of indices associated with the accuracy of the diagnostic performance of GP73, including the sensitivity and specificity, were pooled using Meta Disc 1.4 software. Data were presented as forest plots, and summary receiver operating characteristic (SROC) curve analysis was used to summarize the overall test performance. Eleven studies were included in this meta-analysis. The summary estimates for serum GP73 in diagnosing HCC were as follows: Sensitivity, 77% [95% confidence interval (CI), 75-79%]; specificity, 91% (95% CI, 90-92%); positive likelihood ratio, 4.34 (95% CI, 2.19-8.59); negative likelihood ratio, 0.30 (95% CI, 0.26-0.36) and diagnostic odds ratio, 15.78 (95% CI, 6.95-35.83). The area under the SROC curve was 0.8638, and the Q index was 0.7944. S...Continue Reading

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Citations

Oct 21, 2018·Cell Proliferation·Yanyan XiaNongyue He
Nov 22, 2019·Journal of Zhejiang University. Science. B·Yu-Huan BaiYan-Jing Gao
Dec 5, 2017·Experimental and Therapeutic Medicine·Yujing XiaChuanyong Guo
Nov 30, 2019·Molecular Genetics & Genomic Medicine·Yu ZhangLe-Qun Li
Jun 18, 2020·International Journal of General Medicine·Omaima Mohamed AliWael Abd Elgwad Elsewify
Nov 1, 2017·Current Hepatology Reports·Hager F Ahmed Mohammed, Lewis R Roberts
Jul 11, 2020·Hepatic Oncology·Jiuliang YanQinghai Ye

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Methods Mentioned

BETA
ELISA
glycosylation

Software Mentioned

Stata
Meta Disc

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