Golimumab as the first monthly subcutaneous fully human anti-TNF-alpha antibody in the treatment of inflammatory arthropathies

Immunotherapy
Gabor Hutas

Abstract

Golimumab (Simponi, Centocor Ortho Biotech Inc., PA, USA) is the first transgenic human monoclonal antibody against TNF-alpha that has been approved in the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Golimumab is synthesized using conventional hybridoma technique after immunizing transgenic mice containing human immunoglobulin genes. The constant region of golimumab is identical to that of infliximab, but the variable regions of golimumab have fully human sequences. In this article, we present the pharmacodynamic and pharmacokinetic properties as well as the clinical efficacy and tolerability of golimumab.

References

Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Torben LaursenSanne Fisker
Feb 9, 2006·Annals of the Rheumatic Diseases·T PhamD van der Heijde
Feb 9, 2006·Annals of the Rheumatic Diseases·J C DavisS van der Linden
Oct 9, 2007·Annals of the Rheumatic Diseases·P I SidiropoulosD T Boumpas
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Christopher BrightlingYassine Amrani
Jan 18, 2008·Annals of the Rheumatic Diseases·W NiedbalaF Y Liew
Feb 16, 2008·Annals of the Rheumatic Diseases·A M BlomR Holmdahl
Dec 17, 2008·Annals of the Rheumatic Diseases·D E FurstM H Weisman
Jan 9, 2010·Annals of the Rheumatic Diseases·D W Scott, A S De Groot

❮ Previous
Next ❯

Citations

Aug 30, 2014·Cytokine & Growth Factor Reviews·Lisa M Sedger, Michael F McDermott
Feb 26, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Won Moon
Jan 29, 2019·Genes and Immunity·M Eugenia Delgado, Thomas Brunner
Nov 14, 2019·Digestive Diseases and Sciences·Fabrizio BossaAngelo Andriulli
May 13, 2018·International Journal of Molecular Sciences·Sophie SteelandRoosmarijn E Vandenbroucke

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
phage-display

Software Mentioned

SAVE
GO
FORWARD
MORE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.