PMID: 2505793Sep 1, 1989Paper

Gonadal and sex steroid feedback regulation of gonadotrophin mRNA levels and secretion in neonatal male and female rats

Journal of Molecular Endocrinology
P Pakarinen, I Huhtaniemi

Abstract

Serum and pituitary LH and FSH, and their pituitary mRNA levels, were measured in neonatal male and female rats after gonadectomy and after gonadectomy with sex steroid replacement. The animals were gonadectomized on day 3 of life, and those given sex steroid replacement were implanted with silicone elastomer capsules containing testosterone for males and diethylstilboestrol for females. Sham-operated rats served as controls. The animals were killed 4 or 8 days latter and the sera and pituitaries collected. Pituitary contents of mRNAs for the alpha subunit, FSH-beta and LH-beta were determined by blot hybridization using corresponding cDNAs. Distinct sex differences were found in the mRNA responses to gonadectomy and steroid replacement. In the males, gonadectomy increased all mRNA levels at 7 days of age. In the females, a rise on day 7 was detected only for FSH-beta; the other mRNAs were increased on day 11 of age. The steroid replacements reversed all the post-gonadectomy increases of mRNAs in both sexes. Moreover, the common alpha and LH-beta mRNAs of the male animals were consistently suppressed below control levels. The serum concentrations of gonadotrophins increased after gonadectomy on day 7 in the males but only on da...Continue Reading

Citations

Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·F S vom SaalW V Welshons
Jan 1, 1991·Annals of the New York Academy of Sciences·I T HuhtaniemiD W Warren
Jan 19, 2012·American Journal of Physiology. Endocrinology and Metabolism·Takahiro NemotoTamotsu Shibasaki
May 1, 1993·The American Journal of Physiology·M Bergendahl, I Huhtaniemi

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