Gonadal findings in cryptorchid boys with Noonan's phenotype

European Urology
A OkuyamaT Sonoda

Abstract

7 patients with Noonan's syndrome, aged 5-16 years, complicated by bilateral cryptorchidism were examined by LH-RH and HCG stimulation tests, long-term HCG stimulation and testicular biopsy. 2 patients showed a good response and there was no effects in the remainder. Histological examination of the tests confirmed interstitial fibrosis in every case and showed abnormalities of the seminiferous tubules in 4 patients while in 1 patient the seminiferous tubules were composed of spermatocytes and spermatids. These hormonal and histological findings show different patterns of disturbance of the pituitary-gonadal system in male patients with Noonan's syndrome.

Citations

Apr 1, 1984·The Journal of Urology·M NistalM P Bravo
Jun 27, 2002·Current Urology Reports·Evan J Kass
Oct 17, 2018·European Journal of Endocrinology·Sophie MoniezThomas Edouard
Jan 26, 2016·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Nov 10, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Robert Bendon, Alexander Asamoah
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