Gonadal function and testicular histology in males with Prader-Willi syndrome

Endocrinology, Diabetes & Metabolism
Satoko MatsuyamaAtsushi Mizokami

Abstract

Cryptorchidism is common in Prader-Willi syndrome (PWS) males, but the testicular histology in childhood remains uncertain. The association between testicular histology and long-term gonadal function in PWS males is also unknown. To evaluate the relationship between testicular histology in childhood and long-term gonadal function in PWS males. Forty men with PWS were assessed longitudinally at our institute over the past 24 years. Clinical examinations and blood tests for LH, FSH and testosterone levels were compared with normal reference values. Tissue specimens were collected during orchiopexy and analyzed based on Nistal categories. Of nine testes available for pathological assessments, two showed favourable histology (Nistal I) and seven showed unfavourable histology (Nistal II or III). Of five postpubertal males with histology available, four reached puberty spontaneously, but only one reached Tanner stage 5. In a male with favourable histology, LH and FSH were high, but testosterone was normal, though below the average of the reference range. In three males with unfavourable histology, LH was normal, but FSH was highly elevated, and testosterone was at the lower limit of normal. One patient took hCG treatment to induce pu...Continue Reading

References

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Citations

Dec 10, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Rebecca M Harris, Diane E J Stafford
Mar 7, 2021·International Journal of Molecular Sciences·Luigi NapolitanoMassimiliano Creta
Apr 4, 2021·International Journal of Molecular Sciences·Cees NoordamUrs Eiholzer

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Statistical Package for the social sciences
SPSS

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