Gonadal function in men with testicular cancer: biological and clinical aspects

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
P M PetersenA Giwercman

Abstract

This paper reviews current knowledge about the effect of testicular germ cell cancer (TGCC) on gonadal function and of cancer treatment on spermatogenesis and Leydig cell function. It is well documented that testicular cancer is associated with impaired spermatogenic function and some patients already have impairment of Leydig cell function before orchidectomy. The degree of spermatogenic dysfunction is higher than what can be explained by local tumour effect and by a general cancer effect, since patients with other malignant diseases have normal, or only slightly decreased, semen quality. Furthermore, sperm counts after orchidectomy are further reduced to less than half of the values in healthy men, even in patients cured from the cancer disease after orchidectomy alone. These observations are supported by histological investigations which have shown a high prevalence of abnormalities of spermatogenesis in the contralateral testis in patients with unilateral TGCC. The association between testicular cancer and poor gonadal function is very interesting both from a biological and from a therapeutic point of view. Firstly, the increase in incidence of testicular cancer has been suggested to be associated with a general decline in ...Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Oct 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S W HansenH von der Maase
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D P DearnaleyM J Peckham
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N AassN Norman
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P V HansenM Pedersen
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y D Senturia, C S Peckham
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P V HansenJ Hvolby
Apr 1, 1990·Clinical Endocrinology·M O Savage, D G Lowe
Mar 1, 1986·European Journal of Cancer & Clinical Oncology·E D KreuserW Schreml
Jan 1, 1989·The Journal of Endocrinology·S M ShaletG Read
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·A J SwerdlowP G Smith
Apr 1, 1985·British Journal of Urology·T F FordJ P Pryor
Nov 1, 1987·The Journal of Urology·A GiwercmanN E Skakkebaek
May 1, 1988·American Journal of Epidemiology·C H StraderB McKnight
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S P LeitnerD Bajorunas
Mar 1, 1987·The Journal of Urology·P R CarrollR S Chaganti
Apr 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M NijmanD T Sleijfer
Sep 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E ShapiroR J Sherins
Aug 1, 1980·American Journal of Epidemiology·D SchottenfeldR Payne
Mar 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R E DrasgaE E Stevens
Jun 11, 1983·British Medical Journal·M A JewettJ F Harris
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Oct 1, 1994·International Journal of Cancer. Journal International Du Cancer·H O AdamiM Rahu
Apr 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M PetersenN E Skakkebaek
Apr 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F BajorinP Sogani
Jan 1, 1993·Human Reproduction·M L Meistrich
Apr 1, 1996·European Journal of Endocrinology·G PalmieriG Torino
Feb 1, 1996·Human Reproduction·K Van WaeleghemF Comhaire

❮ Previous
Next ❯

Citations

Jul 29, 2005·Cancer Causes & Control : CCC·V Paul Doria-RoseNoel S Weiss
Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G M ColpiG Piediferro
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ken McElreavey, Lluis Quintana-Murci
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N E SkakkebaekJ Müller
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Møller
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Apr 9, 2009·Cancer Research·Philip D AndersonJoseph H Nadeau
Jan 1, 2008·Hereditary Cancer in Clinical Practice·Martijn F Lutke HolzikHarald J Hoekstra
Oct 11, 2003·Current Opinion in Genetics & Development·Peter J Donovan, Maria P de Miguel
Aug 25, 2012·Cellular and Molecular Life Sciences : CMLS·Daniel ChevallierGeorges Pointis
Mar 21, 2007·Environmental Health Perspectives·Milena DurandoMónica Muñoz-de-Toro
Apr 24, 2007·Environmental Health Perspectives·Perinaaz R WadiaAna M Soto
Oct 6, 2000·Environmental Health Perspectives·J M MolineP J Landrigan
Dec 11, 2007·Fertility and Sterility·Taísa Michelucci RibeiroAgnaldo Pereira Cedenho
Sep 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Inge A OlesenNiels E Skakkebaek
Jan 22, 2008·International Journal of Andrology·Si Brask SonneHenrik Leffers
Sep 21, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Ashraf A EwisYutaka Nakahori
Jun 3, 2004·The Lancet Oncology·M F Lutke HolzikR H Sijmons
May 3, 2006·Current Opinion in Genetics & Development·Michiel J Noordam, Sjoerd Repping
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Katrine BayAnna-Maria Andersson
Dec 29, 2005·American Journal of Human Genetics·Katherine L NathansonElizabeth A Rapley
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Ida Norgil DamgaardNiels E Skakkebaek
Feb 2, 2010·Fertility and Sterility·Renato FraiettaAgnaldo Pereira Cedenho
Nov 4, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Whitney R BurnsAshok Agarwal
Jul 8, 2003·Revista do Hospital das Clínicas·Fabio Firmbach PasqualottoAnthony Joseph Thomas
Aug 21, 2007·International Journal of Andrology·E Rapley
Aug 21, 2007·International Journal of Andrology·Inge A OlesenNiels Jørgensen
Mar 26, 2008·European Journal of Endocrinology·Jakob EberhardAleksander Giwercman
Nov 1, 2007·British Journal of Cancer·J CoffeyE A Rapley
Feb 25, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K WeibringG Cohn-Cedermark
Nov 22, 2012·British Journal of Cancer·M BrydøyUNKNOWN Norwegian Urology Cancer Group (NUCG) III study group
Nov 12, 2002·Archives of Andrology·H TomomasaT Umeda
Sep 25, 2004·Human Reproduction·Kirsten L Tryde SchmidtAnders Nyboe Andersen
Nov 3, 2005·Journal of the National Cancer Institute·Marianne BrydøyOlav Dahl
Sep 3, 2016·Molecular and Clinical Oncology·Thierry GilAlexandre Peltier

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