Gonadal function in two siblings with Fanconi's anemia

Hormone Research
G D BerkovitzC J Migeon

Abstract

2 siblings with Fanconi's anemia, 1 male and 1 female, aged 22 and 24 years, respectively, were evaluated at the Johns Hopkins Hospital because of short stature and hypogonadism. Plasma levels of somatomedin-C were normal in both patients, suggesting that the production of biologically active growth hormone was normal in these subjects. In addition, measurements of serum gonadotropins and plasma androgens in our patients, along with data accumulated from previous studies in the literature, show that abnormal sexual development in patients with Fanconi's anemia is due to hypergonadotropic hypogonadism.

Citations

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Nov 30, 2007·Annales d'endocrinologie·F LamineC Ben Slama
Oct 22, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
May 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Krystyna H ChrzanowskaMalgorzata Krajewska-Walasek
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Jul 23, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Inas MazenGhada Kamah

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