Gonadal Functioning and Perceptions of Infertility Risk Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Vicky LehmannJames L Klosky

Abstract

To describe perceptions of infertility risk among adult survivors of childhood cancer, to test the concordance of survivors' risk perceptions and their adult fertility status, and to identify explanatory factors (sociodemographic factors, gonadotoxic treatments, reproductive history, sexual dysfunction) associated with these outcomes. Adult childhood cancer survivors (N = 1,067; without children or a history of pregnancies) completed questionnaires that asked about infertility risk perceptions and participated in physical evaluations, including biomarkers of gonadal functioning (eg, semen analysis, blood hormone levels, menses). Multivariable regression models tested associations between explanatory factors and risk perceptions as well as concordance of perceptions and fertility status. Most childhood cancer survivors (61.9%) perceived themselves at increased risk for infertility, which was significantly associated with sociodemographic factors (older age, white ethnicity, being married/partnered, higher education), gonadotoxic treatments, fertility concerns, previous unsuccessful attempts to conceive, and sexual dysfunction (all P < .05). Laboratory-evaluated impaired gonadal function was found in 24.3% of female and 55.6% of ...Continue Reading

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Citations

Dec 25, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vicky LehmannJames L Klosky
Aug 28, 2020·Journal of Cancer Survivorship : Research and Practice·Greta SommerhäuserMagdalena Balcerek
Feb 19, 2020·Journal of Adolescent and Young Adult Oncology·Lillian R MeachamJordan Gilleland-Marchak
Jul 3, 2020·Journal of Cancer Survivorship : Research and Practice·Kelly NewtonKaren Goddard
Dec 10, 2020·Journal of the Endocrine Society·Maria VogiatziAlan D Rogol
May 18, 2021·Journal of Adolescent and Young Adult Oncology·Alexandra C HimelhochVicky Lehmann
Jul 10, 2021·Fertility and Sterility·Francesca FilippiMonica Terenziani
Oct 7, 2021·Journal of Adolescent and Young Adult Oncology·Ho Yu ChengYin Ting Cheung

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