PMID: 18406759Oct 1, 1996Paper

Gonadal hormone feedback on pituitary gonadotropin genes

Trends in Endocrinology and Metabolism : TEM
M A Shupnik

Abstract

The pituitary gonadotropins LH and FSH, which act on the ovaries and testes to promote gametogenesis and sex steroid production, are regulated by changes in the levels of steroids and gonadal peptides. Steroid feedback can be positive, as demonstrated by the estrogen and LH surge at ovulation, or negative, as demonstrated by the rise in LH and FSH after gonadectomy or reductions in steroid synthesis. Modulatory effects of the steroids estrogen and testosterone may be mediated directly at the level of the pituitary cells, or by alterations in the release of the hypothalamic releasing factor GnRH. Gonadal peptides, including activin and inhibin, have been shown to have direct effects on pituitary cells to alter FSH synthesis specifically, with no effects on LH. Changes in gonadotropin subunit gene transcription and mRNA levels occur very rapidly and have profound effects on physiological levels of the hormones. In this article, the effects of the gonadal steroids and peptides as modifiers of the rat gonadotropin genes in a subunit specific manner are reviewed, and the physiological implications discussed.

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Citations

Aug 8, 1997·Molecular and Cellular Endocrinology·Y S HuangS Dufour
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J F CouseK S Korach
Jun 28, 2011·Acta histochemica·Ivana MedigovićNataša Nestorović
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·J de GierA C Okkens
Jul 28, 2006·Reproduction in Domestic Animals = Zuchthygiene·A C Okkens, H S Kooistra
Feb 4, 2006·Domestic Animal Endocrinology·N J BeijerinkH S Kooistra
Nov 27, 2018·Reproduction in Domestic Animals = Zuchthygiene·Cindy MaenhoudtAlain Fontbonne
Jun 16, 1999·Endocrine Reviews·J F Couse, K S Korach
Jan 25, 2002·Annals of the New York Academy of Sciences·J F Couse, K S Korach

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