Gonadal hormone-induced changes in adult male and female rats exposed to early postnatal handling are not altered by prenatal morphine exposure

Pharmacology, Biochemistry, and Behavior
Romana Slamberová, I Vathy

Abstract

The purpose of the present study was to investigate the long-term effects of early postnatal handling in several gonadal hormone conditions in adult male and female rats exposed prenatally to morphine or saline. An open-field apparatus was used to test locomotor activities such as line crossing, rearing, grooming, and anxiety-like behaviors such as visiting squares alongside the walls of the open field and boli dropping. Postnatal handling increased locomotor activities in gonadally intact males and in all groups of hormone-manipulated females, but did not change them in gonadectomized (GNX) males. Additionally, there was a decrease in anxiety-like behavior in ovariectomized (OVX) females after estradiol benzoate (EB) or EB and progesterone (P) replacement due to handling. Handling did not affect anxiety-like behaviors in OVX females or in GNX or gonadally intact males. Prenatal morphine exposure did not alter any open-field measures in handled or nonhandled animals when compared to saline controls. Thus, the present study demonstrates that early postnatal handling induces long-lasting changes in locomotor and anxiety-like behaviors of adult male and female rats regardless of their prenatal exposure to morphine. These changes a...Continue Reading

References

Nov 1, 1978·Physiology & Behavior·M LeonG K Smith
Jul 24, 1992·Brain Research. Developmental Brain Research·I Vathy, L Katay
Nov 20, 1990·European Journal of Pharmacology·A Fernández-TeruelA Tobeña
Aug 1, 1990·Physiology & Behavior·A Wakshlak, M Weinstock
Sep 1, 1990·Developmental Psychobiology·J E Jans, B C Woodside
Jan 1, 1990·General Pharmacology·J Palermo-Neto, V A Dorce
Apr 1, 1988·Behavioral Neuroscience·P SchnurD Hang
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·I U VathyR J Barfield
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·M X ZarrowV H Denenberg
Oct 1, 1968·Journal of Comparative and Physiological Psychology·R Ader
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·I U VathyR J Barfield
Nov 1, 1995·Journal of Pharmacological and Toxicological Methods·T L Pierce, C Raper
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Mar 31, 1999·The Behavioral and Brain Sciences·R H Fitch, V H Denenberg
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·R WeizmanM Gavish
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·B FernándezM P Viveros
Aug 15, 2000·European Journal of Pharmacology·L A BrottoB B Gorzalka
Jun 19, 2001·Psychoneuroendocrinology·R SlamberováI Vathy

❮ Previous
Next ❯

Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Oct 4, 2017·Frontiers in Pediatrics·Thitinart SithisarnSusan Barron
Aug 1, 2012·Physiological Research·R Šlamberová

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.