Gonadal modulation of in vitro steroidogenic properties of dispersed adrenocortical cells from Sceloporus lizards

General and Comparative Endocrinology
R V CarsiaHenry B John-Alder

Abstract

Effects of adrenal corticosteroids on reproductive and endocrine functions of the gonads are well known, but reciprocal effects of gonadal hormones on the hypothalamo-pituitary-adrenal (HPA) axis and on adrenocortical steroidogenesis in particular have received much less attention. We investigated effects of gonadectomy and testosterone (T) replacement on adrenocortical cell function in a year-long field study of male Sceloporus undulatus (Eastern Fence Lizard) and in a shorter term laboratory study with male Sceloporus jarrovii (Yarrow's Spiny Lizard). We also compared females to males in Sceloporus virgatus (Striped Plateau Lizard) and investigated effects of gonadectomy in short-term laboratory experiment on females of this species. As measured by in vitro production of progesterone (P(4)), corticosterone (B), and aldosterone (ALDO), sensitivity of adrenocortical cells to corticotrophin (ACTH) was lower in control males than females of S. virgatus. In S. jarrovii males, cellular sensitivity to ACTH was reduced by orchiectomy but was not restored to levels of intact controls by T replacement. By contrast, in S. undulatus, cellular sensitivity to ACTH was not affected by orchiectomy alone but was reduced by T replacement in or...Continue Reading

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Citations

Oct 1, 2009·Integrative and Comparative Biology·Henry B John-AlderLinda C Smith
Aug 21, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Vania Regina de AssisFernando Ribeiro Gomes
Sep 1, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Rocco V CarsiaHenry B John-Alder

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