Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse

Journal of Neuroendocrinology
J ClarksonA E Herbison

Abstract

Kisspeptin and its G-protein coupled receptor Gpr54 are essential for the pubertal activation of gonadotrophin-releasing hormone (GnRH) neurones, with Gpr54 mutation or deletion resulting in failed puberty and infertility in humans and mice. The number of kisspeptin-immunoreactive neurones in the rostral periventricular area of the third ventricle (RP3V) increases during pubertal development in concert with the appearance of kisspeptin appositions with GnRH neurones in the mouse rostral preoptic area. We recently demonstrated that the pubertal increase in RP3V kisspeptin neuronal number in females is dependent upon circulating oestradiol levels. The present experiments investigated the potential role of gonadal steroids in the induction of kisspeptin expression in the RP3V during pubertal development in the male mouse. Using immunocytochemistry (ICC), we show that gonadectomy of male pups at postnatal day (P) 20 resulted in a 60-70% reduction in the number of kisspeptin immunoreactive (IR) neurones within the RP3V of P45 mice (P<0.05) compared to sham-treated littermates. We established a profile of circulating testosterone levels during postnatal development in male mice and found that circulating testosterone was low througho...Continue Reading

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Citations

Sep 20, 2012·Endocrinology·Robert L Goodman, Michael N Lehman
Dec 10, 2013·Regulatory Peptides·Miklós JászberényiGyula Telegdy
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jenny Clarkson, Allan E Herbison
Mar 19, 2013·Frontiers in Neuroendocrinology·Jenny Clarkson
Jul 6, 2014·Current Opinion in Neurobiology·Rebecca E Campbell, Allan E Herbison
Apr 6, 2017·The Journal of Endocrinology·Kinuyo IwataHitoshi Ozawa
Jul 22, 2015·Endocrinology and Metabolism·Holly ClarkeChanna N Jayasena
Nov 6, 2014·Biomolecular Concepts·Takenori Onaga
Nov 30, 2019·Acta Histochemica Et Cytochemica·Kinuyo IwataHitoshi Ozawa

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