PMID: 9192291Apr 1, 1997Paper

Gonadal steroid preservation of central synaptic input to hamster facial motoneurons following peripheral axotomy

Journal of Neurocytology
Kathryn J JonesS K Jacob

Abstract

In recent work, we have demonstrated that testosterone propionate accelerates recovery from facial nerve injury in the adult male hamster. Central synaptic stripping following peripheral motor neuron damage is a well-established component of the injury response. Gonadal steroids regulate synaptogenesis in the normal nervous system. In this study, we tested the hypothesis that testosterone propionate administration at the time of facial nerve transection alters the synaptic connectivity of injured facial motoneurons. Adult hamsters were subjected to right facial nerve transection at the level of the stylomastoid foramen. Half the animals received subcutaneous implants of testosterone propionate; the other half were sham implanted. At 5 days postoperative, the animals were killed by intracardiac perfusion-fixation, and the control and axotomized facial nuclear groups from the brainstems of nonhormone- and testosterone propionate-treated animals processed for routine transmission electron microscopy. Quantiative analysis of the synaptic ratio (percent somal membrane covered by synaptic profiles) and the average length of axosomatic synapses was accomplished. The results indicate that axotomy alone resulted in an 81% reduction in t...Continue Reading

Citations

Dec 23, 2003·The Journal of Comparative Neurology·Keith Nolan Fargo, Dale Robert Sengelaub
Nov 15, 2017·Journal of Neurotrauma·Dale R SengelaubXiao-Ming Xu
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Virginia M Sanders, Kathryn J Jones
Dec 31, 2010·Molecular Neurobiology·Bernardo Moreno-LópezDavid González-Forero
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B McEwenT A Milner
Aug 15, 2006·Glia·Luis M Garcia-Segura, Roberto C Melcangi
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Laura E T HetzlerEileen M Foecking
Jul 30, 2011·The Journal of Comparative Neurology·Nichole A MesnardKathryn J Jones
Sep 11, 2010·The Laryngoscope·Sam J MarzoEileen M Foecking
Aug 24, 1999·Journal of Neurobiology·K J JonesN B Kinderman
Feb 9, 2012·The Journal of Comparative Neurology·James S ByersDale R Sengelaub
Dec 18, 2001·Brain Research. Brain Research Reviews·K J JonesM Damaser
Jun 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Andrew J McGovern, George E Barreto
Apr 28, 2009·Frontiers in Neuroendocrinology·Keith N FargoDale R Sengelaub

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