PMID: 19912891Dec 1, 1992Paper

Gonadal steroids regulate number of astrocytes immunostained for glial fibrillary acidic protein in mouse hippocampus

Molecular and Cellular Neurosciences
J K McQueenG Fink

Abstract

The aim of this study was to determine the effect of sex and sex steroids on the distribution of glial fibrillary acidic protein (GFAP) -containing astrocytes in the hippocampal CA1 region of normal, testicular feminized (Tfm/Y) and hypogonadal (hpg) mice. The number of GFAP-immunoreactive (GFAP-IR) cells, assessed by immunohistochemistry, was significantly higher in Tfm/Y and hpg mice than in normal mice. There was no significant sex difference in numbers of GFAP-IR cells in either strain, and no effect of gonadectomy on GFAP-IR cell number in normal mouse hippocampus. In adult male hpg mice, the higher GFAP expression was reduced to normal following treatment with either testosterone or estradiol-17beta, but not 5alpha-dihydrotestosterone. Administration of testosterone from birth significantly reduced the number of hippocampal GFAP-IR cells in both normal and hpg adult mice. These data strongly suggest that the increased number of GFAP-IR astrocytes in the hippocampus is due to the congenital absence of gonadal steroids in hpg mice and androgen insensitivity in Tfm/Y mice. Our findings have important implications for our understanding of the sex steroid modulation of astrocyte reactivity and show that a remarkable degree of ...Continue Reading

References

Oct 15, 1977·Experientia·J M RosenfeldE V YoungLai
Sep 1, 1991·Brain Research. Molecular Brain Research·J PoirierC E Finch
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·O StewardE Lothman
Oct 1, 1988·Experimental Neurology·F H GageD M Armstrong
Oct 1, 1970·The American Journal of Anatomy·W E Stumpf
Sep 19, 1970·Nature·M F Lyon, S G Hawkes

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Citations

Apr 20, 2012·Endocrinology·Eleanor S DrummondAlan R Harvey
Nov 25, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sarah AtwiNeil J MacLusky

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