Gonadectomy and the development of age-dependent polydipsia and the intake of NaCl solutions in the SWR/J mouse.

Physiology & Behavior
N L Schmalbach, C L Kutscher

Abstract

Gonadectomies were performed at 25 days of life in SWR/J mice, a strain known to develop age-dependent nephrogenic diabetes insipidus with females drinking far more than males. Effect of gonadectomy was different for each of the 3 nonreproductive behaviors studied. (1) Ovariectomy reduced the age-dependent polydipsia seen in females, but castration was without effect in males. (2) Castration of males resulted in a lower intake of an isotonic NaCl solution, making the castrated males similar to the sham-operated and ovariectomized females which did not differ. (3) For the short-term activity measurement sham-operated males did not differ from sham-operated females and castrated males did not differ from ovariectomized females. In each sex, gonadectomy reduced activity.

References

Jun 1, 1975·Physiology & Behavior·C L KutscherN L Schmalbach
Mar 1, 1972·Physiology & Behavior·G N Wade
Mar 1, 1974·Behavioral Biology·P Salber, I Zucker
Jul 1, 1974·Physiology & Behavior·C L Kutscher, D G Miller
Apr 1, 1968·Psychological Reports·J W KakolewskiE S Valenstein
Jun 1, 1972·Physiology & Behavior·C B RoubicekM E Douglas
May 15, 1969·Annals of the New York Academy of Sciences·C L Kutscher
Oct 1, 1969·Journal of Comparative and Physiological Psychology·G N Wade, I Zucker
Mar 1, 1970·Physiology & Behavior·G N Wade, I Zucker
Aug 1, 1969·General and Comparative Endocrinology·C D Kochakian
Jul 1, 1969·Journal of Comparative and Physiological Psychology·F W Finger
Jul 1, 1966·Journal of Gerontology·H A GordonB S Wostmann
Feb 1, 1962·Journal of Reproduction and Fertility·S A ASDELLG A SPERLING

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Citations

Mar 1, 1976·Pharmacology, Biochemistry, and Behavior·N L Schmalbach, C L Kutscher
Dec 22, 2014·Neuroscience and Biobehavioral Reviews·Andre S MecawiJuan Arguelles

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