Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats

Developmental Psychobiology
Wendy A KossJanice M Juraska

Abstract

The human prefrontal cortex, important for executive functions, loses gray matter throughout the adolescent period. In rats, our laboratory demonstrated that a loss of neurons between adolescence and adulthood partially underlies the loss of volume, and this loss is greater in females than males. Here, we examine whether being deprived of gonadal hormones before puberty through adulthood influences the number of neurons in the medial prefrontal cortex (mPFC). Prior to puberty, the testes or ovaries were removed in male and female rats. In adulthood, the number of neurons and glia in the mPFC were quantified using unbiased stereology, and the volume of the frontal white matter was measured. Prepubertal ovariectomy resulted in a higher number of neurons and glia and a larger volume of white matter compared to sham control littermates. Castrated males were not different from sham males on any measure. Thus ovarian hormones secreted after puberty influence the cellular composition of the medial prefrontal cortex.

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Citations

Apr 10, 2016·Brain Research·Janice M Juraska, Jari Willing
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Kalynn M Schulz, Cheryl L Sisk
Nov 23, 2016·The Journal of Endocrinology·Natalia PavónSalvador Uribe-Carvajal
May 31, 2017·Developmental Science·Sarah J OrdazBeatriz Luna
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Jessica M Rosin, Deborah M Kurrasch
Mar 15, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Anne-Lise GoddingsBarbara R Braams
Jul 4, 2019·Developmental Psychobiology·Chun Hui J ParkJee Hyun Kim
Jul 20, 2016·Clinical Science·Neza Grgurevic, Gregor Majdic
Sep 12, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Daphna JoelDick Swaab
Nov 22, 2016·Journal of Neuroscience Research·Wendy A Koss, Karyn M Frick
Jan 2, 2021·NeuroImage·Nandita VijayakumarTim Silk
Dec 2, 2020·Psychoneuroendocrinology·Rebecca C KnickmeyerCynthia Shannon Weickert
Oct 27, 2020·Frontiers in Neuroscience·Hanista PremachandranMaithe Arruda-Carvalho
Feb 26, 2021·Developmental Psychobiology·Carly M DrzewieckiJanice M Juraska
Mar 5, 2019·Experimental Neurology·Sheryl E ArambulaCourtney L Robertson
Sep 15, 2020·Developmental Cognitive Neuroscience·Janice M Juraska, Carly M Drzewiecki
May 15, 2021·Seminars in Cell & Developmental Biology·Kristen DelevichLinda Wilbrecht
Aug 8, 2021·International Journal of Molecular Sciences·Sara TrovaPaolo Peretto
Sep 1, 2021·Journal of Neuroendocrinology·Carly M DrzewieckiJanice M Juraska
Jul 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tiffany C HoIan H Gotlib

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