Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin alpha-subunit gene

Molecular Endocrinology
K KananenI Huhtaniemi

Abstract

We have developed a transgenic (TG) mouse model for gonadal tumorigenesis expressing the Simian virus 40 T-antigen (Tag) under the mouse inhibin alpha-subunit promoter. Gonadal tumors appear with 100% penetrance by the age of 5-8 months in the TG mice. When 1-month-old TG mice were gonadectomized, adrenal gland tumors were observed in each animal (12 females, 11 males) at the age of 6-8 months. No adrenal tumors were detected in gonadectomized non-TG mice (nine females, nine males) or in the intact TG mice (n > 100). The tumors appeared to originate from the X zone of the adrenal cortex. The TG mice with adrenocortical tumors had elevated serum levels of progesterone, estradiol, and immunoreactive inhibin (including dimeric forms), but corticosterone secretion was reduced. The lack of adrenal tumors in intact TG mice suggested that the tumorous gonads secrete factor(s) inhibiting adrenal tumorigenesis. As a candidate molecule, we studied the effects of inhibin, which was high in the serum of control females and TG females with ovarian tumors, as well as in TG males with testicular tumors. The DNA synthesis, as well as the levels of inhibin-alpha and Tag mRNA expression, were significantly reduced by recombinant human inhibin A ...Continue Reading

Citations

May 1, 2009·Endocrine Reviews·Alex C KimGary D Hammer
Jan 5, 2008·Molecular Endocrinology·Robert S VigerMarkku Heikinheimo
Feb 28, 2013·Journal of Cell Science·Marcin ChruscielNafis A Rahman
Jun 16, 2010·PLoS Genetics·Isabelle Sahut-BarnolaAntoine Martinez
Nov 1, 2001·Journal of Endocrinological Investigation·F A LószióM Szécsi
Dec 6, 2003·Molecular and Cellular Endocrinology·Eric Fynn-ThompsonJose Teixeira
Dec 5, 2003·Molecular and Cellular Endocrinology·T Rajendra KumarMartin M Matzuk
Jul 5, 2011·Molecular and Cellular Endocrinology·Johannes Hofland, Frank H de Jong
Dec 1, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Constanze Hantel, Felix Beuschlein
Dec 19, 2015·Molecular and Cellular Endocrinology·Kaitlin J BashamGary D Hammer
Aug 12, 2008·Trends in Endocrinology and Metabolism : TEM·Sophie BernichteinIlpo Huhtaniemi
Jan 9, 2007·Molecular and Cellular Endocrinology·Helka ParviainenMarkku Heikinheimo
Nov 15, 2008·Molecular and Cellular Endocrinology·Sophie BernichteinIlpo Huhtaniemi
Jul 30, 2016·Frontiers in Endocrinology·Felicia LecciaAntoine Martinez
Nov 16, 2004·Molecular and Cellular Endocrinology·William E RaineyBernard P Schimmer
Nov 16, 2004·Molecular and Cellular Endocrinology·Nafis A Rahman, Ilpo T Huhtaniemi
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Sara Galac, David B Wilson
Mar 16, 2005·Molecular and Cellular Endocrinology·Sanne KiiveriMarkku Heikinheimo
Jan 31, 2017·Molecular and Cellular Endocrinology·Milena DoroszkoNafis A Rahman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.