Gonadectomy reduces the density of androgen receptor-immunoreactive neurons in male rat's hippocampus: testosterone replacement compensates it

Behavioral and Brain Functions : BBF
Sajjad MoghadamiHossein Amini

Abstract

In the present study, the role of gonadectomy on memory impairment and the density of androgen receptor-immunoreactive neurons in rats' hippocampus as well as the ability of testosterone to compensate of memory and the density of androgen receptors in the hippocampus was evaluated. Adult male rats (except intact-no testosterone group) were bilaterally castrated, and behavioral tests performed 2 weeks later. Animals bilaterally cannulated into lateral ventricles and then received testosterone (10, 40 and 120 µg/0.5 µl DMSO) or vehicle (DMSO; 0.5 µl) for gonadectomized-vehicle group, 30 min before training in water maze test. The androgen receptor-immunoreactive neurons were detected by immunohistochemical technique in the hippocampal areas. In the gonadectomized male rats, a memory deficit was found in Morris water maze test on test day (5th day) after DMSO administration. Gonadectomy decreased density of androgen receptor-immunoreactive neurons in the rats' hippocampus. The treatment with testosterone daily for 5 days attenuated memory deficits induced by gonadectomy. Testosterone also significantly increased the density of androgen receptor-immunoreactive neurons in the hippocampal areas. The intermediate dose of this hormone ...Continue Reading

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Citations

Feb 15, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M JahanshahiG Bahlakeh
Feb 8, 2020·Biomolecules·Mark D Spritzer, Ethan A Roy
Feb 3, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sydney A RowsonGretchen N Neigh
Dec 25, 2019·International Journal of Endocrinology·Mahmoud Mustafa Ali AbulmeatySuhail Razak
Oct 17, 2019·Frontiers in Endocrinology·Daniel Pantoja EstumanoMoisés Hamoy

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