Gonadoblastoma: an unusual ovarian tumor

Annals of Diagnostic Pathology
Mario GorositoAna Lía Nocito

Abstract

Gonadoblastomas are unusual benign neoplasias that frequently appear in the dysgenetic gonads of women with chromosome Y anomaly. In this study, we reviewed 3 gonadoblastoma cases, 2 of which were bilateral, in patients 21, 17, and 18 years of age. Two of them presented 46 XY karyotype and gonadal dysgenesis, whereas the third presented 46 XX karyotype. Besides, 2 of the cases were associated to dysgerminomas. In all the cases, the histologic examination showed germ cell proliferation and sex cords derivatives frequently surrounding small round deposits containing amorphous hyaline material resembling Call-Exner bodies. One of the patients died at 8 years from diagnosis because of dysgerminoma multiple metastases, one is alive with no evidence of disease at the second year of follow-up, and the evolution of the third patient remains unknown.

References

Nov 1, 1995·Genes, Chromosomes & Cancer·P SaloA de la Chapelle
Oct 6, 2005·Pediatric Blood & Cancer·Antoine De BackerFrans W J Hazebroek
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Aleksander Talerman, Lawrence M Roth

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Citations

Dec 4, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M SantalhaJ A Cidade-Rodrigues
Sep 25, 2019·Journal of Ovarian Research·Ana R FloresFátima Gärtner

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