Gonadotrophin-releasing hormone agonist therapy for hirsutism is as effective as high dose cyproterone acetate but results in a longer remission

Human Reproduction
E Carmina, R A Lobo

Abstract

Both cyproterone acetate (CPA) and the gonadotrophin-releasing hormone agonist (GnRHa) have been shown to be effective for the treatment of hirsutism. We wished to compare the effectiveness of CPA in two standard doses with GnRHa and add-back therapy and to compare the length of remission after these treatments. A total of 60 hirsute hyperandrogenic women was assigned to the following treatment groups: CPA 2 mg with 35 microg of ethinylestradiol for 21 days each month (Diane group), CPA 50 mg, days 5-15, and ethinylestradiol 50 microg, days 5-25, each month (CPA group) or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group). Hirsutism was graded by the Ferriman-Gallwey-Lorenzo (FGL) index and anagen hair shaft diameters and serum luteinizing hormone (LH) and testosterone were assessed before and every 3 months during and after treatment. All women were treated for 1 year with 1 year follow-up. At baseline hirsutism and endocrine patterns were similar in all groups. After one year of treatment, hirsutism decreased in all groups but the changes were greater (P <0.05) in the CPA and GnRHa groups than in the Diane group. ...Continue Reading

Citations

Jan 14, 2003·Fertility and Sterility·Enrico Carmina, Rogerio A Lobo
Jul 20, 1999·Journal of the American Academy of Dermatology·D YüceltenF Durmuşoğlu
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·R S Rittmaster
Jul 25, 2007·American Journal of Clinical Dermatology·Amy T Lee, Lee T Zane
Jun 4, 2014·American Journal of Clinical Dermatology·Najwa Somani, Diane Turvy
Jan 26, 2010·Annales d'endocrinologie·Anne BachelotMarie-Béatrice Galand-Portier
May 23, 2015·Expert Opinion on Pharmacotherapy·Morena Luigia RoccaMichele Morelli
Jun 1, 2004·Expert Review of Pharmacoeconomics & Outcomes Research·Franco LumachiCarla Scaroni
Oct 6, 2004·Expert Opinion on Investigational Drugs·Bulent O Yildiz
Feb 28, 2002·Expert Opinion on Investigational Drugs·Enrico Carmina
Dec 3, 2003·Annals of the New York Academy of Sciences·Vincenza BruniPaolo Vangelisti
Apr 28, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·J BitzerA Lopes da Silva Filho
Mar 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Kathryn A MartinRobert L Rosenfield
Apr 29, 2015·The Cochrane Database of Systematic Reviews·Esther J van ZuurenNikolaos Pandis
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·E Carmina
May 1, 2008·Expert Review of Endocrinology & Metabolism·Shahla Nader

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