Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma?

Human Reproduction
Noa HaskyRuth Shalgi

Abstract

Can gonadotrophin-releasing hormone agonists (GnRH-a) preserve long-term fertility when administered prior to and concomitantly with chemotherapy? GnRH-a display a differential protective effect on fertility, depending upon the specific chemotherapy-induced mechanism of ovarian injury. The role of GnRH-a in fertility preservation has been constantly debated and their use is considered experimental due to conflicting clinical evidence and paucity of data regarding their mechanism for ovarian protection. In vivo model: 7-8 weeks old imprinting control region (ICR) mice were injected with GnRH-a (Leuprolide-acetate) or saline prior to and concomitantly with cyclophosphamide, doxorubicin or saline and sacrificed at various time-points on a longitudinal follow-up; 24 h (n = 36), 1 week (n = 40), 1 month (n = 36) and 9 months (n = 66) post chemotherapy treatment. Blood samples were drawn on Day 0 and on a monthly basis after chemotherapy treatment. On the day of sacrifice, blood samples were drawn and ovaries excised and processed for either immunohistochemistry (IHC), protein or RNA extraction. In vitro model: 21-23 days old Wistar-derived rats were sacrificed, their ovaries excised and primary granulosa cells (PGC) were either isol...Continue Reading

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Citations

Dec 19, 2015·Fertility and Sterility·Hadassa RonessDror Meirow
Oct 8, 2015·Molecular Human Reproduction·Mattan LeviIrit Ben-Aharon
Sep 12, 2015·Future Oncology·Charlotte SonigoMichael Grynberg
Jun 8, 2019·Human Reproduction·P May-PanloupV Duranthon
Dec 6, 2019·International Journal of Molecular Sciences·Paola ScaruffiLucia Del Mastro
Mar 25, 2017·Molecular Reproduction and Development·Shiri Uri-BelapolskyRuth Shalgi
Mar 31, 2019·Journal of Nephrology·Claudio Ponticelli, Richard J Glassock
Nov 14, 2019·International Journal of Molecular Sciences·Charlotte SonigoMichaël Grynberg
Aug 9, 2019·Clinical Medicine Insights. Reproductive Health·Francesca PoggioLucia Del Mastro

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