Gonadotrophin-releasing hormone analogue or dienogest plus estradiol valerate to prevent pain recurrence after laparoscopic surgery for endometriosis: a multi-center randomized trial

Acta Obstetricia Et Gynecologica Scandinavica
Roberta GraneseGaspare Cucinella

Abstract

To evaluate the efficacy of dienogest + estradiol valerate (E2V) and gonadotrophin-releasing hormone analogue (GnRH-a) in reducing recurrence of pain in patients with chronic pelvic pain due to laparoscopically diagnosed and treated endometriosis. Multi-center, prospective, randomized study. Three university departments of obstetrics and gynecology in Italy. Seventy-eight women who underwent laparoscopic surgery for endometriosis combined with chronic pelvic pain. Post-operative administration of dienogest + E2V for 9 months (group 1) or GnRH-a monthly for 6 months (group 2). A visual analogue scale was used to test intensity of pain before laparoscopic surgery at 3, 6 and 9 months of follow up. A questionnaire to investigate quality of life was administered before surgery and at 9 months of follow up. The visual analogue scale score did not show any significant differences between the two groups (p = 0.417). The questionnaire showed an increase of scores for all women compared with pre-surgery values, demonstrating a marked improvement in quality of life and health-related satisfaction with both treatments. No significant differences were found between the groups. The rate of apparent endometriosis recurrence was 10.8% in grou...Continue Reading

References

Feb 1, 1992·British Journal of Obstetrics and Gynaecology·E J Thomas
Nov 1, 1993·Fertility and Sterility·V MaisG B Melis
Feb 24, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN ACOG Committee on Practice Bulletins--Gynecology
Aug 21, 2003·Human Reproduction Update·Paolo VercelliniPier Giorgio Crosignani
May 26, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jacques DonnezJean Squifflet
Jul 3, 2004·Current Opinion in Obstetrics & Gynecology·Ray Garry
Sep 21, 2005·Human Reproduction Update·A Fauconnier, C Chapron
Dec 13, 2005·Journal of Minimally Invasive Gynecology·Erica WeirRose Kung
Dec 13, 2005·Journal of Minimally Invasive Gynecology·Michele VignaliMauro Busacca
Nov 14, 2006·Journal of Minimally Invasive Gynecology·Frances R Batzer
Jan 19, 2008·Expert Opinion on Pharmacotherapy·Allison K Rodgers, Tommaso Falcone
Feb 5, 2008·American Journal of Obstetrics and Gynecology·Paolo VercelliniPier Giorgio Crosignani
Feb 9, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Y CheongI Cooke
May 9, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R GraneseG Cucinella
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Apr 30, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L Savelli
Jun 18, 2011·Archives of Gynecology and Obstetrics·Felice PetragliaThomas Strowitzki
Jul 28, 2011·International Journal of Women's Health·Adolf E Schindler
Apr 13, 2013·Archives of Gynecology and Obstetrics·Gaspare CucinellaAntonino Perino
Jan 18, 2014·Human Reproduction·G A J DunselmanUNKNOWN European Society of Human Reproduction and Embryology

❮ Previous
Next ❯

Citations

Nov 17, 2015·Expert Opinion on Pharmacotherapy·Emanuela TafiSimone Ferrero
Dec 2, 2015·Expert Opinion on Investigational Drugs·Umberto Leone Roberti Maggiore, Simone Ferrero
Feb 19, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kazushige AdachiTadashi Kimura
May 6, 2016·BioMed Research International·Peter von TheobaldCatherine Quantin
May 18, 2016·Expert Opinion on Drug Metabolism & Toxicology·Giovanni GrandiAngelo Cagnacci
May 12, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexis D GreeneKatherine A Burns
Nov 8, 2016·Fertility and Sterility·Paolo VercelliniSilvano Bosari
Jul 13, 2018·The Journal of Obstetrics and Gynaecology Research·Kuniaki OtaHideki Mizunuma
Jan 22, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Giovanni GrandiFabio Facchinetti
Dec 26, 2017·Current Obstetrics and Gynecology Reports·Parveen ParasarKathryn L Terry
May 23, 2018·The Cochrane Database of Systematic Reviews·Julie BrownAndrew Prentice
Aug 11, 2018·Frontiers in Pharmacology·Yi ChenPanhong Li
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
May 27, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marcello CeccaroniSimone Ferrero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.