PMID: 2121394Aug 1, 1990Paper

Gonadotrophin-releasing hormone and human chorionic gonadotrophin tests reveal that both hypothalamic and testicular endocrine functions are suppressed during acute prolonged physical exercise

Clinical Endocrinology
U M KujalaI T Huhtaniemi

Abstract

The mechanism of suppression of gonadotrophins and testosterone during prolonged exercise was studied. Fourteen healthy males were injected immediately before an exhaustive bicycle run for 4 h, and before a control period without exercise, with one of the following substances: (1) 1 ml of saline, (2) 100 micrograms of a GnRH agonist (buserelin), and (3) 50 IU/kg of hCG. Each test was repeated for each subject 2 weeks apart, in a randomized single-blind fashion. Blood samples were taken before the injections (sample A), 6 h after the injections (sample B), and the following morning (sample C). During placebo treatment testosterone concentration decreased from A samples to B samples more in the exercise trial than in rest trial (31 vs 8%, P = 0.02). This exercise-associated decrease was reversed by both the GnRH agonist and hCG treatments. Serum gonadotrophin concentrations responded identically to GnRH agonist injections during exercise and rest trials. hCG resulted in a greater increase of serum testosterone from A to C samples at rest than during the exercise trial (52 vs 33%, P = 0.04). In conclusion, the exercise-induced suppression of serum testosterone is associated with two effects: suppressed endogenous GnRH stimulation ...Continue Reading

References

Jan 1, 1990·Journal of Steroid Biochemistry·M HärkönenI Huhtaniemi
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·C MouginR C Gaillard
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Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·T J VasankariI T Huhtaniemi
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·H W Baker
Mar 1, 2012·La Presse médicale·Jean-Christophe Maiza, Stéphane Schneebeli
Jun 17, 2015·Experimental Gerontology·Juha P AhtiainenKeijo Häkkinen
Nov 5, 2005·Acta Physiologica Hungarica·A C HackneyK K Brownlee
Dec 17, 2014·Ageing Research Reviews·Hui-Hui Liu, Jian-Jun Li
May 20, 2005·Endocrine Reviews·Jean M Kaufman, Alex Vermeulen
Sep 14, 2018·Medicine and Science in Sports and Exercise·Kidmealem Zekarias, Rupendra T Shrestha
Jul 14, 2000·Physiological Reviews·B K Pedersen, L Hoffman-Goetz
Apr 17, 2018·Revista Andaluza De Medicina Del Deporte·D VaamondeA C Hackney
Mar 16, 2021·Exercise and Sport Sciences Reviews·Paola LunettiAlessandra Ferramosca
Jul 15, 2021·Hormones : International Journal of Endocrinology and Metabolism·Nazli KhajehnasiriReihaneh Sadeghian

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