Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome

The Cochrane Database of Systematic Reviews
Nienke S WeissM van Wely

Abstract

Ovulation induction with follicle stimulating hormone (FSH) is the second-line treatment in women with polycystic ovary syndrome (PCOS) who do not ovulate or conceive on clomiphene citrate (CC). To compare the effectiveness and safety of gonadotrophins as a second-line treatment for ovulation induction in women with CC-resistant PCOS. We searched the Menstrual Disorders & Subfertility Group's Specialist Register of controlled trials, the Cochrane Central Register of Controlled Trials, MEDLINE (1966 to October 2014), EMBASE (1980 to October 2014), CINAHL (1982 to October 2014), National Research Register and web-based trials databases such as Current Controlled Trials. There was no language restriction. All randomised controlled trials reporting data on comparing clinical outcomes in women with PCOS who did not ovulate or conceive on CC, and undergoing ovulation induction with urinary FSH (uFSH: FSH-P or FSH-HP), HMG/HP-HMG or recombinant FSH. We included trials reporting on ovulation induction followed by intercourse or intrauterine insemination. We excluded studies that used co-treatment with CC, metformin, LH or letrozole. Three review authors (NW, MN and MvW) independently selected studies for inclusion, assessed study quali...Continue Reading

References

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Citations

Nov 2, 2016·The Cochrane Database of Systematic Reviews·Kunyan ZhouChi Eung Danforn Lim
Jul 10, 2018·Endocrine Reviews·Ross C AndersonRobert P Millar
Jan 17, 2019·The Cochrane Database of Systematic Reviews·Nienke S WeissMadelon van Wely
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Julie Brown, Cindy Farquhar
Jun 5, 2021·The Cochrane Database of Systematic Reviews·Kunyan ZhouChi Eung Danforn Lim

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