PMID: 2105507Feb 1, 1990Paper

Gonadotropin and prolactin secretion following intraventricular administration of morphine in gilts

Proceedings of the Society for Experimental Biology and Medicine
M J EstienneC E Estienne

Abstract

The effects of central nervous system administration of morphine on secretion of luteinizing hormone (LH), follicle-stimulating hormone, and prolactin were investigated in ovariectomized gilts stereotaxically implanted with lateral ventricular cannulas. In Experiment 1, mean serum LH and follicle-stimulating hormone concentrations and serum LH pulse frequency were unaffected by artificial cerebrospinal fluid administration (P greater than 0.1), but decreased (P less than 0.01) in 8 of 11 gilts when 500 micrograms of morphine were given 3 hr later. Serum LH pulse amplitude was unaffected (P greater than 0.1) by cerebrospinal fluid or morphine injection. In Experiment 2, luteinizing hormone concentrations decreased (P less than 0.0001) and prolactin concentrations increased (P less than 0.0001), but follicle-stimulating hormone concentrations did not change (P greater than 0.1) after 500 micrograms of morphine. Gonadotropin responses to 10 micrograms of gonadotropin-releasing hormone, given 2 hr after intraventricular injection, were similar (P greater than 0.1) for morphine- and cerebrospinal fluid-treated gilts. These results indicate that morphine inhibits LH secretion at the level of the central nervous system, and are consis...Continue Reading

Citations

Feb 1, 1993·Physiology & Behavior·J RushenA M De Passillé
Jan 1, 1991·Domestic Animal Endocrinology·C R BarbG B Rampacek
Oct 24, 2002·Journal of Neuroscience Methods·Frank J C M van Eerdenburg, John A J Dierx
Feb 1, 1997·Journal of Neuroscience Methods·S T AndersonJ D Curlewis
Mar 15, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Clay A LentsJ Joe Ford
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·C Richard BarbGary J Hausman
Nov 13, 2010·Animal Reproduction Science·Guihong YangXun Li
Jun 2, 2005·Domestic Animal Endocrinology·M J Estienne, C R Barb
Mar 25, 2017·Biology of Reproduction·Jennifer F ThorsonClay A Lents

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