Gonadotropin-releasing hormone agonist combined with hormone replacement therapy does not improve the reproductive outcomes of frozen-thawed embryo transfer cycle in elderly patients: a retrospective study.

Reproductive Biology and Endocrinology : RB&E
Mei DongFenghua Liu

Abstract

With the rapid development of whole embryo freezing technology, more and more frozen-thawed embryo transfer (FET) was used in assisted reproductive technology. However, the best FET program for elderly women has not been finalized. We intended to explore the reproductive outcomes of traditional hormone replacement treatment and a gonadotropin-releasing hormone agonist (GnRHa) combined with hormone replacement treatment in the frozen-thawed embryo transfer cycle of elderly patients. In this retrospective analysis, we analyzed 1264 elderly patients (aged 38 years or older) who underwent FET at three reproductive centers between 2015 and 2017. According to the endometrial preparation protocol, we divided the patients into a GnRHa combined with hormone replacement treatment (GnRHa-HRT) group and traditional hormone replacement treatment (HRT) group. The clinical pregnancy, ongoing pregnancy, live birth, and abortion rates were compared between groups. One-way analysis of variance of the two groups revealed no significant difference in the clinical (33.58% vs. 37.15%) and ongoing pregnancy rates (19.40% vs. 25.10%) between the GnRHa-HRT and HRT groups. The live birth rate (17.54% vs. 24.10% p = 0.0229) of the GnRHa-HRT group was low...Continue Reading

References

Sep 1, 1996·Molecular Reproduction and Development·L Janny, Y J Menezo
Jul 28, 2011·Taiwanese Journal of Obstetrics & Gynecology·Mahnaz AshrafiTahereh Madani
Feb 9, 2012·Journal of Assisted Reproduction and Genetics·Brian M Berger, James A Phillips
Jun 13, 2013·Human Reproduction·Zdravka VelevaHannu Martikainen
Oct 5, 2014·Reproductive Biomedicine Online·A van de VijverC Blockeel
Nov 2, 2014·The Cochrane Database of Systematic Reviews·Mohamed A F M YoussefMadelon van Wely
Feb 26, 2015·Fertility and Sterility·Robert F Casper
Nov 28, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Haiyan GuoYanping Kuang
Feb 22, 2017·Reproductive Biology·Carlos DosoutoPeter Humaidan
Sep 25, 2017·Journal of Assisted Reproduction and Genetics·Kemal OzgurKevin Coetzee

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Methods Mentioned

BETA
hormone replacement treatment
pregnancy test
hormone replacement

Software Mentioned

SAS9
SAS

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