Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: systematic review and meta-analysis of randomized trials

Cancer Treatment Reviews
Lucia Del MastroPaolo Bruzzi

Abstract

The role of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) in the prevention of chemotherapy-induced premature ovarian failure (POF) is still controversial. We conducted a systematic review and meta-analysis of randomized trials evaluating the efficacy of GnRHa, given before and during chemotherapy, in the prevention of POF in premenopausal cancer patients. Studies were retrieved by searching PubMed, Web of Knowledge database and the proceedings of major conferences. We calculated Odds Ratios (OR) and 95% confidence intervals (CIs) for POF from each trial and obtained pooled estimates through the random effects model as suggested by DerSimonian and Laird. Nine studies were included in the meta-analysis with 225 events of POF occurring in 765 analyzed patients. The pooled OR estimate indicates a highly significant reduction in the risk of POF (OR=0.43; 95% CI: 0.22-0.84; p=0.013) in patients receiving GnRHa. There was statistically significant heterogeneity among studies (I(2)=55.8%; p=0.012). There was no evidence of publication bias. Subgroups analyses showed that the protective effect of GnRHa against POF was similar in subgroups of patients defined by age and timing of POF assessment, whi...Continue Reading

References

Jan 1, 1987·Cancer Chemotherapy and Pharmacology·J H WaxmanJ S Malpas
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 2, 2002·Journal of Health Services Research & Policy·Julian HigginsDouglas Altman
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 26, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K AltundagM Gunduz
Oct 29, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Del MastroM Venturini
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
Jan 16, 2007·BMJ : British Medical Journal·John Fletcher
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ann PartridgeEric Winer
Sep 14, 2007·Breast Cancer Research and Treatment·Ander UrruticoecheaIan E Smith
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie R Schover
Oct 1, 2008·Human Reproduction Update·Zeev Blumenfeld, Michael von Wolff
Oct 14, 2008·Menopause : the Journal of the North American Menopause Society·Sunyoung LeeYoung-Taek Oh
Mar 14, 2009·Journal of Women's Health·Megan E B ClowseLori A Bastian
Jun 24, 2010·Breast Cancer Research and Treatment·Irit Ben-AharonSalomon M Stemmer
Nov 5, 2010·Clinical Obstetrics and Gynecology·S Samuel KimBrian Petroff
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernd GerberUNKNOWN German Breast Group Investigators
Jan 10, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K BehringerP Borchmann
Jan 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela N MunsterSusan E Minton
Nov 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle DemeestereYvon Englert
May 28, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N H TurnerL Biganzoli
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alison W LorenUNKNOWN American Society of Clinical Oncology
Jul 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F A PeccatoriUNKNOWN ESMO Guidelines Working Group

❮ Previous
Next ❯

Citations

Apr 1, 2015·Expert Opinion on Pharmacotherapy·Zeev Blumenfeld, Ayelet Evron
Nov 7, 2015·Annals of Medicine·Charlotta Dabrosin
Jan 6, 2016·Current Opinion in Supportive and Palliative Care·Catherine BenedictJoanne F Kelvin
Jan 23, 2016·Clinical Journal of Oncology Nursing·Joanne Frankel Kelvin
Jan 6, 2016·BMC Medicine·Matteo LambertiniPaola Anserini
Oct 21, 2015·Critical Reviews in Oncology/hematology·Maria VassilakopoulouAmanda Psyrri
Apr 4, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Michael von WolffDominik Denschlag
Nov 17, 2015·Endocrinology and Metabolism Clinics of North America·Stephanie J Estes
Sep 24, 2015·Obstetrics and Gynecology·Matteo LambertiniLucia Del Mastro
Sep 24, 2015·Obstetrics and Gynecology·Eman ElgindyAmany Abdelghani
Sep 24, 2014·Reproductive Biomedicine Online·Shun-Jen TanChi-Huang Chen
Mar 18, 2015·Women's Health·Kate Maclaran, Nick Panay
May 18, 2016·Critical Reviews in Oncology/hematology·Mahmoud SalamaPeter Mallmann
Aug 12, 2015·Current Opinion in Supportive and Palliative Care·Ruth Ronn, Hananel Holzer
Jun 16, 2015·Journal of Women's Health·Kate E WaimeyMary Ellen Pavone
Apr 20, 2016·Journal of Endocrinological Investigation·A Podfigurna-StopaB Meczekalski
Jan 13, 2015·International Journal of Oncology·Francesco RecchiaSilvio Rea
Jun 18, 2014·The Breast : Official Journal of the European Society of Mastology·Nicoletta Tomasi-ContFrederic Amant
Mar 5, 2015·The New England Journal of Medicine·Halle C F MooreUNKNOWN POEMS/S0230 Investigators
Dec 31, 2014·Journal of breast cancer·Han-Byoel Lee, Wonshik Han
Dec 10, 2014·Current Opinion in Obstetrics & Gynecology·Matteo LambertiniAnn H Partridge
Jun 3, 2016·Future Oncology·Zeev Blumenfeld
Oct 14, 2014·PloS One·Pawel WilkoszPeter Fedorcsak
Jun 3, 2016·Current Opinion in Obstetrics & Gynecology·Zeev Blumenfeld, Ayelet Evron
Sep 20, 2016·Climacteric : the Journal of the International Menopause Society·M F Garrido-Oyarzún, C Castelo-Branco
Nov 3, 2016·Journal of Ovarian Research·Maurizio GuidaCarmine Selleri
Jun 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela N Munster
Mar 27, 2015·Biology of Reproduction·Alison Y Ting, Brian K Petroff
Apr 6, 2018·Journal of Pediatric Hematology/oncology·Mariaclaudia MeliAndrea Di Cataldo
Jan 30, 2018·Clinical and Experimental Reproductive Medicine·Hoon KimSeok Hyun Kim
May 20, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Kimberly BlomMichelle A Hladunewich
May 14, 2019·Climacteric : the Journal of the International Menopause Society·S Hunt, B Vollenhoven

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.