Gonadotropin-releasing hormone and norepinephrine release from the rabbit mediobasal and anterior hypothalamus during the mating-induced luteinizing hormone surge

Endocrinology
A H KaynardH G Spies

Abstract

The release of hypothalamic GnRH in association with the mating-induced LH surge was studied in the rabbit. Push-pull perfusion (PPP) of the mediobasal (MBH) or anterior (AH) regions of the hypothalamus was performed on conscious, unrestrained does for 3 h before and 5 h after exposure to a vasectomized buck. In experiment 1, GnRH concentrations were measured by RIA in 20-min fractions of MBH-PPP. An approximately 100-fold increase in GnRH release was observed within 1 h of coitus (pre, 1.15 +/- 0.29 pg/ml; peak, 106.67 +/- 37.42 pg/ml; n = 6; P less than 0.05). Concomitant surges of LH and PRL in the peripheral circulation were observed. In experiment 2, GnRH and norepinephrine (NE) were measured (the latter by radioenzymatic assay) in 10-min fractions of MBH-PPP. A 218% postcoital rise in NE levels (n = 5; P less than 0.05) in MBH-PPP accompanied an approximately 50-fold peak rise in GnRH in the same samples (pre, 1.57 +/- 0.23 pg/ml; peak, 76.52 +/- 50.14 pg/ml; P less than 0.05). MBH-NE, MBH-GnRH, LH, and PRL release began rising within 10 min of coitus. In experiment 3, GnRH was measured in 20 min fractions of AH-PPP. Coitus induced a marked rise in AH-GnRH release (precoitus, 0.31 +/- 0.03 pg/ml; peak, 2.25 +/- 0.80 pg/ml...Continue Reading

Citations

Jul 23, 1993·Neuroscience Letters·R C McRee, D C Meyer
Jun 6, 2000·Brain Research. Molecular Brain Research·M CabaH G Spies
Jan 1, 1997·Brain Research Bulletin·E F RissmanR P Millar
Jul 7, 2000·Frontiers in Neuroendocrinology·J Bakker, M J Baum
Jan 14, 1999·The American Journal of Physiology·K M HoegerJ D Veldhuis
Jul 5, 2019·Archives of Sexual Behavior·Wendy Verónica Herrera-MoralesLuis Núñez-Jaramillo
Mar 9, 2021·Frontiers in Veterinary Science·Rodrigo A CarrascoGregg P Adams

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