PMID: 7546241Mar 1, 1995Paper

Gonadotropin releasing hormone (GnRH) agonist induces down-regulation of the CD3+CD25+ lymphocyte subpopulation in peripheral blood

American Journal of Reproductive Immunology : AJRI
H N HoT J Gill

Abstract

To test whether GnRH agonist could alter in vivo human immune cells and whether the alteration is related to the success of pregnancy in an in vitro fertilization-embryo transfer (IVF-ET) program. Thirty-six infertile patients were enrolled under the long protocol of GnRH agonist (buserelin acetate) and superovulation with gonadotropin from our IVF-ET program. Peripheral B cells, NK cells, CD4+ and CD8+ T cells, and the expression of CD69, CD25, HLA-DR, and CD71 antigens on the T cells were serially examined by dual-color flow cytometry. B cells, NK cells, CD8+ T cells, and CD71+ T lymphocyte subpopulations were not changed throughout the whole course of treatment. CD4+ T cell and CD25+ T cell subpopulations were significantly down-regulated when the GnRH agonist was used for approximately 2 wk. CD3+CD69+, CD3+CD25+, and CD3+DR+ lymphocyte subpopulations were increased at 7 days (during implantation) and at 14 days after embryo transfer in pregnant patients, but not in patients who failed to get pregnant. The GnRH agonist had a transiently immunosuppressive effect on CD4+ and CD25+ T cells, but CD69+, CD25+, and HLA-DR+ T cells were activated during and after successful implantation.

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Citations

Jun 1, 1997·Obstetrics and Gynecology·C C HsuK E Huang
Sep 1, 1996·Developmental and Comparative Immunology·I A Ayoub, T J Yang
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·G EmonsA V Schally
Jun 16, 2001·International Immunopharmacology·J D Jacobson
Feb 24, 2001·Acta Dermato-venereologica·P HelmboldU F Haustein
Jul 4, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Amitabha Ray, Monica Ficek
Nov 21, 2000·Rheumatic Diseases Clinics of North America·S E Walker, J D Jacobson
Jun 14, 2016·American Journal of Reproductive Immunology : AJRI·Nayoung SungJoanne Kwak-Kim
Apr 23, 2013·Case Reports in Obstetrics and Gynecology·Djavid I AlleemudderSallie Davies

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