Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function.

Frontiers in Neuroendocrinology
Margaret E WiermanStuart A Tobet

Abstract

GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the cribriform plate, then progress caudally to sites within the hypothalamus where they halt and send projections to the median eminence to activate pituitary gonadotropes. Many factors controlling this precise journey have been elucidated by the silencing or over-expression of candidate genes in mouse models. Importantly, a number of these factors may not only play a role in normal physiology of the hypothalamic-pituitary-gonadal axis but also be mis-expressed to cause human disorders of GnRH deficiency, presenting as a failure to undergo normal pubertal development. This review outlines the current cadre of candidates thought to modulate GnRH neuronal migration. The further elucidation and characterization of these factors that impact GnRH neuron development may shed new light on human reproductive disorders and provide potential targets to develop new pro-fertility or contraceptive agents.

References

Jun 1, 1992·Current Opinion in Genetics & Development·A Ballabio, G Camerino
Mar 9, 1989·Nature·M Schwanzel-Fukuda, D W Pfaff
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S WrayH Gainer
Oct 1, 1989·Journal of Steroid Biochemistry·P H SeeburgK Nikolics
May 1, 1972·The Journal of Comparative Neurology·V S Caviness, R L Sidman
Sep 25, 1997·Human Molecular Genetics·H R MacDonald, R Wevrick
Oct 27, 1997·The Journal of Biological Chemistry·K L BennettP S Linsley
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Sep 16, 1999·American Journal of Human Genetics·E I Rugarli
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·L M OliveiraM Vallejo
Aug 31, 2001·Biochemical and Biophysical Research Communications·A HoriM Fujino
Dec 12, 2001·Molecular and Cellular Endocrinology·S A TobetG A Schwarting
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alessandro IeraciCarola Ponzetto
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jennifer LeCouterNapoleone Ferrara
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Jan 31, 2004·The European Journal of Neuroscience·Gerald A SchwartingStuart Tobet
Feb 27, 2004·Biochimica Et Biophysica Acta·Napoleone FerraraFranklin Peale

❮ Previous
Next ❯

Citations

Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew I Koemeter-CoxKirk Mykytyn
Sep 26, 2014·International Journal of Endocrinology·Marco MarinoManuela Simoni
Apr 1, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ana FortunaAmílcar Falcão
May 30, 2012·Biology of Sex Differences·Ashlyn Swift-GallantD Ashley Monks
Dec 12, 2012·Seminars in Cell & Developmental Biology·Paolo Giacobini, Vincent Prevot
Apr 19, 2011·Molecular and Cellular Endocrinology·Youli Hu, Pierre-Marc Bouloux
Mar 15, 2016·Frontiers in Endocrinology·Tomoko SogaIshwar S Parhar
Dec 25, 2015·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Katherine E KaugarsPaul D Heideman
Mar 20, 2016·Cellular and Molecular Life Sciences : CMLS·Dhananjay Huilgol, Shubha Tole
Apr 23, 2015·The Journal of Endocrinology·Tony M Plant
May 20, 2015·The Journal of Clinical Investigation·Anna CariboniChristiana Ruhrberg
Apr 29, 2015·Frontiers in Neuroendocrinology·Tony M Plant
May 8, 2013·Molecular and Cellular Endocrinology·Smita Salian-MehtaMargaret E Wierman
Oct 14, 2014·Frontiers in Neuroendocrinology·Paolo E Forni, Susan Wray
May 3, 2016·Nature Neuroscience·Andrea MessinaVincent Prevot
Aug 29, 2012·PLoS Genetics·Naresh Kumar HanchateCatherine Dodé
Nov 3, 2016·Rare Diseases·Christina SpilkerMichael R Kreutz
Jun 16, 2017·Brain Structure & Function·Zaid MohsenCarol F Elias
May 4, 2017·Development·Yuanyuan Xie, Richard I Dorsky
Jan 31, 2014·The Journal of Clinical Endocrinology and Metabolism·S Salian-MehtaM E Wierman
Dec 30, 2014·Molecular Endocrinology·Gabriele Di SanteRichard G Pestell
May 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna BerghardLeif Carlsson
May 23, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C L TanC L Jasoni
Oct 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yongting ZhaoHui Che
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yunyong MaRussell D Fernald
May 21, 2011·Human Molecular Genetics·Wanda S LaymanDonna M Martin
Mar 19, 2019·Frontiers in Cellular Neuroscience·Ed Zandro M TarocPaolo E Forni
Nov 16, 2018·Brain and Neuroscience Advances·John A Russell
Jul 4, 2020·Annals of Pediatric Endocrinology & Metabolism·Christoffer Højrup RenaultAnders Juul
Sep 19, 2014·The Journal of Veterinary Medical Science·Shoko NakamutaIsato Araki
May 16, 2020·Veterinary Sciences·Dillon K JarrellMark A Brown
Dec 23, 2020·Open Biology·Guillaume Poncelet, Sebastian M Shimeld

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.