PMID: 7522953Nov 1, 1994Paper

Gonadotropin-releasing hormone receptor in gynecologic tumors. Frequent expression in adenocarcinoma histologic types

Cancer
A ImaiT Tamaya

Abstract

Gonadotropin-releasing hormone (Gn-RH) analogs have been used in the therapy of the endocrine-dependent cancers. The authors attempted to determine the frequency with which Gn-RH receptor (Gn-RHR) is present in gynecological cancers. Experiments were performed on gynecologic tumors that had been surgically removed and their cloned cell lines. Gn-RHR was characterized by [3H]Gn-RH binding to plasma membrane preparations. Gn-RHR messenger ribonucleic acid was determined by reverse transcription-polymerase chain reaction using oligonucleotide primers synthesized according to the published human Gn-RHR sequence. High affinity binding sites with nanomolar range of Kd and Gn-RHR mRNA were detected in a high proportion (over 90%) of the specimens from endometrium (6 of 6) and endometrial carcinomas (16 of 17), myometrium (6 of 6) and myomas (4 of 5), epithelial carcinoma (21 of 23), and stromal tumors (3 of 3) of the ovary. There was no substantial Gn-RHR in cervical carcinomas or germ cell-derived tumors of the ovary. Cloned cell lines gave identical results to those obtained in their respective mother tumors. We detected Gn-RHR in a wide range of the carcinomas and tissues originating from the endometrium and ovary, but not in the u...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1992·Annals of Clinical Biochemistry·A ImaiT Tamaya
Jan 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·G EmonsK D Schulz
May 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·K IidaT Tamaya
Sep 13, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G S PahwaG Emons
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C LiebowA V Schally
Dec 14, 1991·BMJ : British Medical Journal·F H Schröder
Oct 1, 1991·British Journal of Obstetrics and Gynaecology·C J GallagherH F Hope-Stone
Jan 1, 1989·British Journal of Cancer·A L HarrisM Dowsett
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D González-BarcenaA V Schally
Jun 30, 1989·Biochemical and Biophysical Research Communications·G S PahwaG Emons
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B SzendeA V Schally
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C LiebowA V Schally
Dec 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·G SrkalovicA V Schally
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y SharoniA V Schally
Feb 1, 1989·European Journal of Cancer & Clinical Oncology·G EmonsR Knuppen
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·K A EidneR P Millar
Feb 1, 1986·Endocrine Reviews·A ManniD Max
Jun 1, 1987·The British Journal of Surgery·B A Greenway
Mar 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·A V SchallyT W Redding
Apr 1, 1994·Molecular and Cellular Endocrinology·J S DavidsonR P Millar
Jan 1, 1994·Annals of Clinical Biochemistry·A ImaiT Tamaya
Feb 1, 1993·Molecular and Cellular Endocrinology·L ChiS C Sealfon
Sep 1, 1993·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. ImaiT. Tamaya

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Citations

May 16, 1997·International Journal of Cancer. Journal International Du Cancer·M L KottlerR Counis
Apr 1, 1997·Endocrine·A Chamson-ReigC Libertun
Nov 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Lorenzo AlonsoCamelia Baha
Jul 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A ImaiT Tamaya
Mar 18, 1999·Hematology/oncology Clinics of North America·G Emons, J J Kavanagh
Nov 1, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L PaskeviciuteA Engelholm
Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H ZhengS Fu
Oct 10, 2006·Gynecologic and Obstetric Investigation·Atsushi ImaiTsukasa Ohno
Apr 3, 2001·Expert Opinion on Investigational Drugs·P LimontaR M Moretti
May 20, 2000·American Journal of Obstetrics and Gynecology·A ImaiT Tamaya
Jul 27, 1999·Gynecologic Oncology·J H KimS E Namkoong
Oct 14, 2005·British Journal of Cancer·J HasanG C Jayson
Sep 15, 2005·Journal of Neuroendocrinology·J P HapgoodK Ronacher
Feb 3, 2006·American Journal of Reproductive Immunology : AJRI·Wei-Hsiung YangTerry M Nett
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Roberta M MorettiPatrizia Limonta
Aug 22, 2017·Frontiers in Endocrinology·Carsten Gründker, Günter Emons
Feb 13, 2020·Reproductive Sciences·Jasmine M AlyWilliam H Catherino
Mar 20, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Noriko SuzukiAtsushi Imai
Jul 29, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Hossein Jadvar
Oct 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen V LiuJacek K Pinski
May 22, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Song Yi KoHonami Naora

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