Gonadotropin-releasing hormone regulation of pituitary follistatin gene expression during the primary follicle-stimulating hormone surge

Endocrinology
A C Bauer-DantoinJ L Jameson

Abstract

Follistatin is produced in the gonadotrope and folliculostellate cells of the pituitary gland and is thought to indirectly regulate FSH biosynthesis and secretion through its ability to bind activin. Recent measurements of follistatin gene expression during the rat estrous cycle revealed a marked increase in pituitary follistatin messenger RNA (mRNA) levels at the time of the preovulatory FSH surge. This finding suggests a role for follistatin in the regulation of FSH at this dynamic time of the cycle. The aim of the present study was to identify the hormonal control mechanisms responsible for stimulating follistatin gene expression on proestrus. In particular, the roles of estrogen (E) and GnRH were assessed using an in vivo ovariectomized (OVX) animal model in which steroid priming results in daily gonadotropin surges. Follistatin mRNA and serum FSH levels were unchanged throughout the day in untreated OVX rats. E priming of OVX rats elicited a 2-fold elevation in follistatin mRNA levels between 1600-2000 h coincident with the peak of the E-induced FSH surge. To determine whether this effect of E on follistatin mRNA levels was the result of the direct or indirect effects of E on the pituitary, follistatin mRNA levels were exa...Continue Reading

Citations

Feb 15, 2012·Molecular and Cellular Endocrinology·Louise M BilezikjianWylie W Vale
Jun 15, 2011·Molecular and Cellular Endocrinology·So-Youn KimTeresa K Woodruff
Sep 29, 2004·Molecular and Cellular Endocrinology·Louise M BilezikjianWylie W Vale
Nov 4, 1998·Frontiers in Neuroendocrinology·D J Phillips, D M de Kretser
Mar 9, 2007·Biology of Reproduction·Weiming ZhengLisa M Halvorson
Oct 17, 2003·Biology of Reproduction·Kathleen A PrendergastJohn C Marshall
Apr 19, 2006·Endocrine Journal·Sachiko KiharaHitoshi Okamura
May 16, 2021·Human Pathology·Luvy DelfinSylvia L Asa

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