PMID: 7019716Jul 16, 1981Paper

Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary

Nature
P M ConnA R Means

Abstract

Calcium (Ca2+) seems to have an informational role in many tissues. In particular, it fulfills the requirements of a second messenger for gonadotropin releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release from the pituitary gonadotrope (see ref. 1 for review). Very little is known about the effect of this ion on intracellular targets or the mechanism by which Ca2+ mobilization stimulates LH release. One intracellular target for Ca2+ is calmodulin, a ubiquitous intracellular Ca2+ receptor that has been shown to modulate many cellular functions, including cyclic nucleotide and glycogen metabolism, protein phosphorylation, microtubule assembly and disassembly, a Ca2+ flux, and the activities of NAD kinase, tryptophan 5' monooxidase and phospholipase A2 (see refs 2-5 for reviews). We have now used a specific and sensitive radioimmunoassay to determine the quantity and distribution of calmodulin in the gonadotrope before and during GnRH-stimulated LH release. The data indicate that GnRH stimulates redistribution of calmodulin from the cytosol to the plasma membrane and suggest that the molecule may have a role in the mechanism of stimulus-secretion coupling.

References

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Citations

Jan 1, 1982·Diabetologia·S TomlinsonB L Brown
Aug 1, 1989·Pflügers Archiv : European journal of physiology·J P GardnerS R Harris
Dec 1, 1981·Journal of Steroid Biochemistry·A R Means, J G Chafouleas
Dec 1, 1985·Journal of the Neurological Sciences·A H Schapira, R A Hutton
Sep 14, 1984·Biochimica Et Biophysica Acta·Y Shechter, Y I Henis
Jan 1, 1992·Brain Research. Molecular Brain Research·L A Mangels, M E Gnegy
Jan 1, 1986·Molecular and Cellular Endocrinology·F Nakamura, F Yoshimura
Mar 1, 1988·Molecular and Cellular Endocrinology·C H Wooge, P M Conn
Mar 1, 1988·Molecular and Cellular Endocrinology·F J ValadezP M Conn
Jan 1, 1984·Biochimica Et Biophysica Acta·M L VeiglW D Sedwick
Jan 1, 1989·Domestic Animal Endocrinology·B Alston-MillsL W Douglass
Feb 13, 1992·European Journal of Pharmacology·J M TrifaróA Rodríguez Del Castillo
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A AntipenkoR Cussó
Nov 26, 2002·Biochimica Et Biophysica Acta·Sonja L Toutenhoofd, Emanuel E Strehler
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J Blum, P M Conn
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Z NaorJ Hermon
Dec 1, 1982·The Journal of Cell Biology·G A NelsonM J Karnovsky
Apr 1, 1983·The Journal of Cell Biology·R S GarofaloB H Satir
Mar 1, 1984·The Journal of Cell Biology·W J DeeryB R Brinkley
Nov 2, 2005·Molecular and Cellular Biology·Takashi BabaYoshiaki Fujii-Kuriyama
Dec 1, 1993·Journal of Cellular Physiology·N A KhanJ P Moulinoux
Nov 1, 1985·Journal of Steroid Biochemistry·P M ConnM Bates
Jul 11, 2012·Journal of Neuroendocrinology·P MelamedL Pnueli
Jun 15, 1984·Biochemical and Biophysical Research Communications·C Rochette-Egly, M G Tovey
Jan 1, 1982·Journal of Cellular Biochemistry·A R MeansJ G Chafouleas
May 1, 1985·Journal of Neurochemistry·L W ZhouB Weiss
Aug 1, 1985·Clinical Endocrinology·B L BrownS Tomlinson
Jan 1, 1987·Annals of the New York Academy of Sciences·J M Trifaró, S Fournier

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