Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo.

Breast Cancer Research : BCR
Carsten GründkerGünter Emons

Abstract

Triple-negative breast cancer does not express estrogen and progesterone receptors, and no overexpression/amplification of the HER2-neu gene occurs. Therefore, this subtype of breast cancer lacks the benefits of specific therapies that target these receptors. Today chemotherapy is the only systematic therapy for patients with triple-negative breast cancer. About 50% to 64% of human breast cancers express receptors for gonadotropin-releasing hormone (GnRH), which might be used as a target. New targeted therapies are warranted. Recently, we showed that antagonists of gonadotropin-releasing hormone type II (GnRH-II) induce apoptosis in human endometrial and ovarian cancer cells in vitro and in vivo. This was mediated through activation of stress-induced mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK), followed by activation of proapoptotic protein Bax, loss of mitochondrial membrane potential, and activation of caspase-3. In the present study, we analyzed whether GnRH-II antagonists induce apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells that express GnRH receptors. In addition, we ascertained whether knockdown of GnRH-I receptor expression affects GnRH-II antagonist-induc...Continue Reading

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Citations

Jun 27, 2013·Apoptosis : an International Journal on Programmed Cell Death·Yi LuLu-Yuan Li
Feb 1, 2011·Breast Cancer Research and Treatment·Antje SchubertCarsten Gründker
Jun 24, 2015·Women's Health·Simona Di Lascio, Olivia Pagani
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Jan 10, 2018·Frontiers in Endocrinology·Amy T DesaulniersBrett R White
May 17, 2012·The Journal of Pharmacology and Experimental Therapeutics·Nilasha BanerjeeReina Bendayan
Aug 22, 2017·Frontiers in Endocrinology·Carsten Gründker, Günter Emons
Jan 1, 2014·Chinese Journal of Integrative Medicine·Li-li ZangZe-yao Tang
Jun 15, 2011·Current Opinion in Obstetrics & Gynecology·Orkun Tan, Orhan Bukulmez
Oct 22, 2019·Frontiers in Oncology·Maira Huerta-ReyesArturo Aguilar-Rojas
Jan 20, 2016·International Journal of Oncology·Arturo Aguilar-RojasGuadalupe Maya-Núñez
Mar 7, 2021·Cells·Carsten Gründker, Günter Emons

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