PMID: 7544532Aug 1, 1995Paper

Gonadotropin-stimulated regulation of blood-follicle barrier is mediated by nitric oxide

The American Journal of Physiology
R W PowersW J Larsen

Abstract

Although initially described over 30 years ago, the blood-follicle barrier has remained a biological enigma. In this study, we characterize the blood-follicle barrier with respect to its regulation of intrafollicular inter-alpha-trypsin inhibitor protein (I alpha I) influx after an ovulatory stimulus. We have found that I alpha I is localized within the ovarian vasculature but is excluded from the follicular compartment until an ovulatory stimulus is given. Within minutes after an ovulatory dose of human chorionic gonadotropin, I alpha I is localized within the follicular fluid of responding follicles where this protein becomes associated with and stabilizes the newly synthesized hyaluronic acid-rich cumulus extracellular matrix. Analysis of this process has shown that intravenous injection of sodium nitroprusside or excess substrate for nitric oxide synthase, L-arginine, mimics the effect of gonadotropic hormones on the influx of I alpha I into the follicular compartment of preovulatory follicles. Moreover, intravenous injection of specific nitric oxide synthase inhibitors, NG-nitro-L-arginine methyl ester and NG-nitro-L-arginine, inhibits gonadotropin-mediated intrafollicular influx of I alpha I and also inhibits ovulation in...Continue Reading

References

Jul 1, 1976·Acta Endocrinologica·D G CranM F Hay
Sep 15, 1990·Lancet·T NakakiR Kato
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·A G Byskov
Nov 1, 1993·Endocrinology·M MorettoA Negro-Vilar
Sep 30, 1993·Biochemical and Biophysical Research Communications·A KomarovC S Lai
Nov 1, 1951·The Anatomical Record·J H BURR, J I DAVIES

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