Gonadotropin stimulation increases the expression of angiotensin-(1--7) and MAS receptor in the rat ovary.

Reproductive Sciences
Virgínia M PereiraAdelina M dos Reis

Abstract

We have previously shown the presence of immunoreactive angiotensin-(1-7) [Ang-(1-7)] in rat ovary homogenate and its stimulatory effect on estradiol and progesterone production in vitro. In the current study, we investigated the presence and cellular distribution of Ang-(1-7) and the Mas receptor, the expression of Mas and angiotensin-converting enzyme 2 (ACE2) messenger RNA (mRNA), and the enzymatic activity in the rat ovary following gonadotropin stimulation in vivo. Immature female Wistar rats (25 days old) were injected subcutaneously (SC) with equine chorionic gonadotropin (eCG, 20 IU in 0.2 mL) or vehicle 48 hours before euthanasia. Tissue distributions of Ang-(1-7), Mas receptor, and ACE2 were evaluated by immunohistochemistry, along with angiotensin II (Ang II) localization, while the mRNA expression levels of Mas receptor and ACE2 were evaluated by real-time polymerase chain reaction (PCR). In addition, we determined the activity of neutral endopeptidase (NEP), prolyl endopeptidase (PEP), and ACE by fluorometric assays. After eCG treatment, we found strong immunoreactivity for Ang-(1-7) and Mas primarily in the theca-interstitial cells, while Ang II appeared in the granulosa but not in the thecal layer. Equine chorion...Continue Reading

References

Jul 1, 1991·Journal of Hypertension·W R WelchesC M Ferrario
Aug 1, 1990·Cell and Tissue Research·W G Thomas, C Sernia
Jan 1, 1989·American Journal of Obstetrics and Gynecology·A PalumboF Naftolin
May 1, 1989·American Journal of Hypertension·G AguileraJ P Harwood
Apr 1, 1988·The American Journal of the Medical Sciences·F M BumpusA Husain
Jun 17, 1988·Science·A PellicerF Naftolin
Sep 29, 1988·Nature·T R JacksonM R Hanley
Jan 1, 1994·The Journal of Clinical Investigation·Y YoshimuraY Nakamura
Jul 1, 1997·Frontiers in Neuroendocrinology·Y Yoshimura
Mar 13, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A MedeirosK M Carvalho
Sep 20, 2000·Biology of Reproduction·E V SolovyevaA Tsafriri
Apr 17, 2003·Endocrinology·Amilton P R CostaAdelina M Dos Reis
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Feb 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·John R PepperellMaricruz Merino
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Lenice K BeckerMaria J Campagnole-Santos
Mar 4, 2008·Experimental Physiology·Robson A S SantosAna Cristina Simões E Silva
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·E Y Adashi, R M Rohan

❮ Previous
Next ❯

Citations

Apr 3, 2010·Journal of Molecular Histology·Augusto B ReisFernando M Reis
Nov 20, 1985·Biochimica Et Biophysica Acta·E T CánepaM Grinstein
Oct 25, 2013·International Journal of Molecular Sciences·Pei-Pei PanFan Jin
Nov 3, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Paulo Bayard GonçalvesJoão Francisco Oliveira
Jun 12, 2012·Journal of Molecular Histology·João Vaz-SilvaFernando M Reis
Dec 19, 2015·Research in Veterinary Science·Alécio Matos PereiraAmilton Raposo Costa
Jun 15, 2011·Experimental Physiology·Gregorio E N VianaAdelina M Reis
Dec 20, 2012·Clinical Science·Danielle G Passos-SilvaRobson A S Santos
Sep 12, 2014·Histochemistry and Cell Biology·María Gabriela MoralesClaudio Cabello-Verrugio
Jul 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tawar QaradakhiAnthony Zulli
Nov 9, 2016·Reproductive Sciences·Angela PalumboFrederick Naftolin
Mar 15, 2018·Reproduction in Domestic Animals = Zuchthygiene·M P De CesaroPbd Gonçalves
Aug 10, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lukas SchwentnerChristine Wulff
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Apr 13, 2017·Human Reproduction·Ines K CavalloFernando M Reis
Jul 2, 2020·International Journal of Molecular Sciences·Kamila Domińska
Sep 3, 2020·Journal of Molecular Histology·Virginia M PereiraAdelina M Reis
Oct 4, 2020·Journal of the Chinese Medical Association : JCMA·Hsin-Hui HuangCheng-Chang Chang
Aug 10, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Joabel Tonellotto dos SantosPaulo Bayard Gonçalves
Jun 15, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Marcos Henrique BarretaPaulo Bayard Dias Gonçalves
Sep 24, 2014·Pharmacological Reviews·Michael BaderRobson A Santos
May 5, 2020·Molecular Human Reproduction·Yan JingChen Fei
Nov 10, 2020·Journal of Dietary Supplements·Sreus A G NaiduA Satyanarayan Naidu
Nov 26, 2020·American Journal of Physiology. Endocrinology and Metabolism·Narasimhan KothandaramanMelvin Khee Shing Leow
Feb 2, 2021·Saudi Journal of Biological Sciences·Nesrein M HashemAyman A Swelum
May 30, 2020·Reproductive Biomedicine Online·Rong LiJie Qiao
Mar 19, 2021·Reproduction, Fertility, and Development·G Taru SharmaSaiKumar Guttula
May 12, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoAdva Aizer
May 15, 2021·Reproductive Biology and Endocrinology : RB&E·Raoul OrvietoAdva Aizer
Aug 28, 2020·Protein and Peptide Letters·Virginia M PereiraAdelina M Reis
Jul 27, 2021·Journal of Endometriosis and Pelvic Pain Disorders·Alexon M RacilanFernando M Reis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrinology
Amilton P Raposo CostaAdelina M dos Reis
Cell and Tissue Research
O von Bohlen und Halbach, D Albrecht
Physiological Reviews
Martin PaulReinhold Kreutz
© 2021 Meta ULC. All rights reserved