Gonadotropin suppression with oral contraceptives before in vitro fertilization

Fertility and Sterility
Y GonenR F Casper

Abstract

One hundred eighty-one stimulation cycles in which gonadotropin suppression with oral contraceptives (OCs) preceded induction of follicle stimulation (study group) and 113 stimulation cycles without pituitary suppression (control group) were compared. The mean length of ovarian suppression was 35.3 +/- 0.9 days. No spontaneous luteinizing hormone (LH) surges occurred when the use of OC preceded ovarian hyperstimulation, whereas in the control group the incidence of LH surges was 19.5%. The mean amount of human menopausal gonadotropin required was significantly lower in the study group than in the control group (8.9 +/- 0.4 and 10.9 +/- 0.4 ampules, respectively). Significantly more follicles greater than or equal to 1.5 cm in diameter were seen on the day before oocyte retrieval and significantly more oocytes were retrieved per attempt in the group with OC pretreatment. Our data clearly demonstrate that OCs are useful in vitro fertilization stimulation protocols to facilitate scheduling of cycles and to prevent spontaneous LH surges.

Associated Clinical Trials

Citations

Apr 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·H Bałakier, R F Casper
Jul 13, 1999·Human Reproduction·V Karande, N Gleicher
Jul 29, 2008·Current Opinion in Obstetrics & Gynecology·Dimitris LoutradisPeter Drakakis
Apr 30, 2008·Annals of the New York Academy of Sciences·Jason Gabriel BromerAydin Arici
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G PadosS Mantalenakis
Sep 8, 2004·Journal of the Society for Gynecologic Investigation·Mohamed F M Mitwally, Robert F Casper
Dec 1, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano PalombaFulvio Zullo
Jan 1, 1997·Journal of Assisted Reproduction and Genetics·A Ben-ChetritE M Greenblatt
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Oct 14, 2008·European Journal of Endocrinology·Catherine Hayden
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser

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